LIVER-TUMORS INDUCED IN RATS BY ORAL-ADMINISTRATION OF THE ANTIHISTAMINIC METHAPYRILENE HYDROCHLORIDE
LIVER-TUMORS INDUCED IN RATS BY ORAL-ADMINISTRATION OF THE ANTIHISTAMINIC METHAPYRILENE HYDROCHLORIDE
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DOI：
10.1126/science.7403848
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发表时间：
1980-01-01
期刊：
影响因子：
56.9
通讯作者：
BLACKWELL, BN
中科院分区：
文献类型：
--
作者：
LIJINSKY, W;REUBER, MD;BLACKWELL, BN
将抗组胺非处方药盐酸美沙吡林以0.1%的浓度与食物混合，给予50只雄性和50只雌性Fischer大鼠。第二组50只雄性和50只雌性大鼠接受相同的治疗，同时在食物中添加0.2%的亚硝酸钠。两组中几乎所有的大鼠都发生了肝肿瘤，主要是肝细胞癌和胆管癌。第一只大鼠在第43周死于肝脏肿瘤。两组中超过50%的大鼠从肝癌转移到远处器官。仅用亚硝酸盐处理的对照大鼠或未经处理的对照大鼠未发生肝肿瘤。亚硝酸盐对盐酸美沙吡林的致癌性没有明显影响。
The antihistaminic over-the-counter drug methapyrilene hydrochloride, mixed with food at a concentration of 0.1 percent, was administered to 50 male and 50 female Fischer rats. A second group of 50 male and 50 female rats was given the same treatment together with 0.2 percent of sodium nitrite added to the food. Almost all of the rats in both groups developed liver neoplasms, mainly hepatocellular carcinomas and cholangiocarcinomas. The first rat died with a liver neoplasm at the 43rd week. Over 50 percent of the rats in both groups had metastases from the carcinomas of the liver to distant organs. Control rats treated with nitrite only, or untreated, did not develop liver neoplasms. There was no discernible effect of nitrite on the carcinogenicity of methapyrilene hydrochloride.