Contributions of mouse models to understanding of age- and noise-related hearing loss
Contributions of mouse models to understanding of age- and noise-related hearing loss
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DOI：
10.1016/j.brainres.2006.03.017
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发表时间：
2006-05-26
期刊：
影响因子：
2.9
通讯作者：
Ohlemiller, Kevin K.
中科院分区：
文献类型：
--
作者：
Ohlemiller, Kevin K.
老鼠曾经是一种奇特的东西，现在已经成为使用最广泛的听力研究模型。它们在噪声性听力损失(NIHL)研究中的价值源于它们对噪音的高度脆弱性，以及通过基因标准化使结果的方差减少成为可能。为了研究与年龄相关的听力损失(ARHL)，他们提供了规模小、寿命短的经济，这两者都降低了住房成本。近亲交配的小鼠品系随着年龄的增长表现出广泛的噪声敏感性和听力损失率。这些可以使用经典的遗传分析，以及利用基因工程的假设驱动的实验来研究。通过这样的调查，目前已经确定了3个促进NIHL的基因座，10个促进ARHL的基因座，以及至少6个促进两者的基因座。所涉及的基因类型意味着动态平衡和保护机制是导致这两种病理类型出现的关键，并支持损伤和某些明显的ARHL之间的因果联系。虽然大多数被研究的小鼠ARHL模型最接近于感觉性ARHL，但最近的工作发现小鼠具有神经和工业ARHL的基本特征。使用这些模型，应该有可能识别促进ARHL主要形式及其组合的基因和等位基因。(C)2006爱思唯尔B.V.保留所有权利。
Once an oddity, mice have become the most widely used hearing research model. Their value for research in noise-induced hearing loss (NIHL) stems from their high vulnerability to noise and reduced variance of results, made possible by genetic standardization. To research in age-related hearing loss (ARHL), they offer economies of small size and a short lifespan, both of which reduce housing costs. Inbred mouse strains show a wide range of noise sensitivities and rates of hearing loss with age. These can be studied using classical genetic analysis, as well as hypothesis-driven experiments utilizing genetic engineering. Through such investigations, presently 3 loci have been identified to date that contribute to NIHL, 10 that promote ARHL, and at least 6 loci that promote both. The types of genes involved implicate homeostatic and protective mechanisms as key to the appearance of either type of pathology and support a causal link between injury and some apparent ARHL. While the majority of mouse ARHL models examined most closely resemble sensory ARHL, recent work has identified mice possessing the essential characteristics of neural and strial ARHL. Using these models, it should be possible to identify genes and alleles that promote the major forms of ARHL and their combinations. (c) 2006 Elsevier B.V. All rights reserved.