METAANALYSIS IN CLINICAL-TRIALS
METAANALYSIS IN CLINICAL-TRIALS
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DOI：
10.1016/0197-2456(86)90046-2
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发表时间：
1986-09-01
期刊：
影响因子：
--
通讯作者：
LAIRD, N
中科院分区：
文献类型：
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作者：
DERSIMONIAN, R;LAIRD, N
本文研究了8篇已发表的综述，每篇综述都报道了几个相关试验的结果。每篇综述汇集了相关试验的结果，以评估某种治疗方法对特定疾病的疗效。这些综述在合并前缺乏对治疗效果均匀性的一致评估。我们讨论了一种随机效应的方法来结合从一系列实验比较两种治疗的证据。这种方法在分析整体治疗效果时纳入了效果的异质性。该模型可以扩展到包括相关协变量，这将减少异质性，并允许更具体的治疗建议。我们建议一个简单的非迭代程序来表征一系列研究中治疗效果的分布。
This paper examines eight published reviews each reporting results from several related trials. Each review pools the results from the relevant trials in order to evaluate the efficacy of a certain treatment for a specified medical condition. These reviews lack consistent assessment of homogeneity of treatment effect before pooling. We discuss a random effects approach to combining evidence from a series of experiments comparing two treatments. This approach incorporates the heterogeneity of effects in the analysis of the overall treatment efficacy. The model can be extended to inlcude relevant covariates which would reduce the heterogeneity and allow for more specific therapeutic recommendations. We suggest a simple noniterative procedure for characterizing the distribution of treatment effects in a series of studies.