RAPIDLY PROGRESSIVE OUTER RETINAL NECROSIS IN THE ACQUIRED-IMMUNODEFICIENCY-SYNDROME
RAPIDLY PROGRESSIVE OUTER RETINAL NECROSIS IN THE ACQUIRED-IMMUNODEFICIENCY-SYNDROME
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DOI：
10.1016/s0002-9394(14)77012-6
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发表时间：
1990-10-15
影响因子：
4.2
通讯作者：
RAO, NA
中科院分区：
文献类型：
--
作者：
FORSTER, DJ;DUGEL, PU;RAO, NA
两名患者，均为人类免疫缺陷病毒血清阳性，发展迅速进行性视网膜坏死与系统性带状疱疹感染。这些患者的视网膜炎的特征是原发性累及外层视网膜，保留内层视网膜和视网膜血管系统，直至疾病过程的晚期;快速进展的过程;对静脉注射阿昔洛韦的反应差;以及发生孔源性视网膜脱离。其中一名患者的视网膜炎最初是多灶性的。其中一名患者的视网膜活检标本的电子显微镜检查显示病毒颗粒与疱疹病毒一致，聚合酶链反应在另一名患者的视网膜活检标本中发现疱疹病毒。这一实体可能代表了一种独特的形式，急性视网膜坏死，是看到免疫功能低下的个人。
Two patients, both seropositive for the human immunodeficiency virus, developed rapidly progressive retinal necrosis associated with a systemic herpes zoster infection. The retinitis in these patients was characterized by primary involvement of the outer retina, with sparing of the inner retina and retinal vasculature until late in the disease process; a rapidly progressive course; poor response to intravenous acyclovir; and development of rhegmatogenous retinal detachment. In one of the patients, the retinitis was initially multifocal. Electron microscopy of a retinal biopsy specimen from one of the patients demonstrated virus particles consistent with a herpesvirus, andpolymerase chain reaction disclosed herpesvirus in a retinal biopsy specimen of the other patient. This entity may represent a distinct form of acute retinal necrosis that is seen in immunocompromised individuals.