Synthetic biology advances for pharmaceutical production.
Synthetic biology advances for pharmaceutical production.
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DOI：
10.1016/j.copbio.2015.02.004
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发表时间：
2015-12
影响因子：
7.7
通讯作者：
Takano E
中科院分区：
文献类型：
--
作者：
Breitling R;Takano E
合成生物学正迅速从概念验证走向工业应用。药物是先进基因工程的一个有前途的目标。基因组序列数据表明，巨大的未充分利用的生物合成能力。合成生物学可以创建富含生物活性的新型化学品库。合成生物学扩大了工业可用底盘生物的范围。合成生物学使新一代微生物工程成为可能，用于制药和其他高价值化学品的生物技术生产。本文综述了该领域的最新进展，描述了新的计算和实验工具的发现，优化和生产的生物活性分子，并概述了这些工具的应用进展，制药生产系统。
Synthetic biology is quickly moving from proof of concept to industrial application. Pharmaceuticals are a promising target for advanced genetic engineering. Genome sequence data indicate vast underexploited biosynthetic capacity. Synthetic biology can create libraries of novel chemicals enriched for bioactivity. Synthetic biology expands the range of available chassis organisms for industry. Synthetic biology enables a new generation of microbial engineering for the biotechnological production of pharmaceuticals and other high-value chemicals. This review presents an overview of recent advances in the field, describing new computational and experimental tools for the discovery, optimization and production of bioactive molecules, and outlining progress towards the application of these tools to pharmaceutical production systems.