Moderate alcohol consumption and lower levels of inflammatory markers in US men and women
Moderate alcohol consumption and lower levels of inflammatory markers in US men and women
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DOI：
10.1016/j.atherosclerosis.2005.06.037
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发表时间：
2006-05-01
期刊：
影响因子：
5.3
通讯作者：
Rimm, EB
中科院分区：
文献类型：
--
作者：
Pai, JK;Hankinson, SE;Rimm, EB
目的：适量饮酒可显着降低心血管疾病 (CVD) 的风险。我们评估了酒精摄入量和炎症标志物之间的关系，以部分解释这种有益作用。方法和结果：通过两项大型前瞻性研究，我们对 959 名健康男性和 473 名健康女性卫生专业人员进行了抽样调查，并报告了酒精摄入量。炎症标志物为可溶性肿瘤坏死因子-α 受体 I 和 2（sTNF-R1 和 sTNF-R2）、C 反应蛋白 (CRP) 和白细胞介素 6 (IL-6)。我们发现随着酒精摄入量的增加，sTNF-R1（P 趋势 < 0.001 男性；0.03 女性）和 sTNF-R2（P 趋势 = 0.002 男性；0.08 女性）呈现显着的反向线性趋势。与不饮酒者相比，平均每天饮酒 1-2 杯的男性 CRP 水平降低 26%（-0.66 mg/L，p = 0.13），IL-6 水平降低 36%（-1.12 pg/ml，p = 0.02）。在女性中，每天喝半杯酒也观察到类似但更强的关联。与不饮酒者相比，每天饮酒 1-2 杯的男性和女性的 sTNF-R1（男性 -9%，女性 -6%）和 sTNFF-R2（男性 -7%，女性 -6%）水平以及 CRP（男性 -10%，女性 -32%）和 IL-6（男性 -45%，女性 -27%）水平显着降低。结论：适量饮酒与较低水平的炎症标志物相关，并可能通过这些机制降低 CVD 风险。 (c) 2005 Elsevier Ireland Ltd. 保留所有权利。
Objective: Moderate alcohol consumption is associated with substantially lower risk of cardiovascular disease (CVD). We assessed the relationship between alcohol intake and inflammatory markers to partially explain this beneficial effect. Methods and results: From two large prospective studies, we sampled 959 healthy male and 473 healthy female health professionals with reported alcohol intake. Markers of inflammation were soluble tumor necrosis factor-alpha receptors I and 2 (sTNF-R1 and sTNF-R2), C-reactive protein (CRP), and interleukin-6 (IL-6). We found significant inverse linear trends for sTNF-R1 (P-trend < 0.001 men; 0.03 women) and sTNF-R2 (p-trend = 0.002 men; 0.08 women) with increasing alcohol intake. Compared to non-drinkers, men who consumed on average 1-2 drinks/day had 26% lower CRP (-0.66 mg/L, p = 0.13), and 36% lower IL-6 (-1.12 pg/ml, p = 0.02) levels. Among women, a similar though stronger association was observed at half drink per day. Compared to non-drinkers, both men and women who consumed 1-2 drinks/drinking day had significantly lower sTNF-R1 (-9% in men, -6% in women) and sTNTF-R2 (-7% in men, -6% in women) levels as well as lower CRP (-10% in men, -32% in women) and IL-6 (-45% in men, -27% in women) levels. Conclusions: Alcohol in moderation is associated with lower levels of inflammatory markers and may lower risk of CVD through these mechanisms. (c) 2005 Elsevier Ireland Ltd. All rights reserved.