Synthesis of 2,11-bis(methylidene)spermine, a new inhibitor of spermine oxidase
Synthesis of 2,11-bis(methylidene)spermine, a new inhibitor of spermine oxidase
复制标题
DOI：
10.1134/s1068162016030080
复制
发表时间：
2016-07-01
影响因子：
1
通讯作者：
Khomutov, A. R.
中科院分区：
文献类型：
--
作者：
Grigorenko, N. A.;Khomutov, M. A.;Khomutov, A. R.
以2-氯甲基-3-氯丙烯-1为起始原料，经6步反应，以较高的收率合成了1，12-二氨基-2，11-二（亚甲基）-4，9-二氮杂十二烷。对新合成的精胺类似物在精胺氧化酶抑制中的应用进行了讨论。
Earlier unknown 1,12-diamino-2,11-bis(methylidene)-4,9-diazadodecane, which may be considered as an enzyme-activated inhibitor of spermine oxidase, was synthesized in 6 steps starting from 2-chloromethyl-3-chloropropene-1 in a high yield. Application of newly synthesized spermine analogue for the inhibition of spermine oxidase was discussed.