Measuring benefits of opioid misuse treatment for economic evaluation: health-related quality of life of opioid-dependent individuals and their spouses as assessed by a sample of the US population
Measuring benefits of opioid misuse treatment for economic evaluation: health-related quality of life of opioid-dependent individuals and their spouses as assessed by a sample of the US population
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DOI：
10.1111/add.13219
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发表时间：
2016-04-01
期刊：
影响因子：
6
通讯作者：
Schackman, Bruce R.
中科院分区：
文献类型：
--
作者：
Wittenberg, Eve;Bray, Jeremy W.;Schackman, Bruce R.
目的了解公众如何看待阿片类药物滥用和阿片类药物使用障碍对个人及其配偶的生活质量影响，以经济评估中使用的术语来衡量。设计2013年12月至2014年1月对美国人口代表受访者小组进行的横断面互联网调查。背景设置美国。参与者总共2054名随机选择的成年人； 51.1% 为男性（加权前）。六种阿片类药物滥用和治疗结果的测量平均值（95% 置信区间）和中位健康效用：主动注射滥用；主动滥用处方；开始时和治疗稳定后的美沙酮维持治疗；和丁丙诺啡治疗开始时和稳定时。效用是与健康相关的生活质量的数字表示，用于经济评估中，以调整估计的生存率，以包括人们对健康状态的偏好。效用是通过调查一般人群来估计他们分配给特定健康状态的价值来确定的，其中 0 = 死亡的价值，1.0 = 完全健康的价值。配偶溢出效用被分配给处于特定健康状态的个人的配偶。研究结果平均个人效用范围为主动注射阿片类药物滥用的 0.574 [95% 置信区间 (CI)=0.538, 0.611] 到稳定丁丙诺啡治疗的 0.766 (95% CI=0.738, 0.795)，其他州介于两者之间。女性受访者认为在起始状态下积极处方滥用和丁丙诺啡治疗的效用高于男性（P
AimsTo understand how the general public views the quality of life effects of opioid misuse and opioid use disorder on an individual and his/her spouse, measured in terms used in economic evaluations.DesignCross-sectional internet survey of a US population-representative respondent panel conducted December 2013-January 2014.SettingUnited States.ParticipantsA total of 2054 randomly selected adults; 51.1% male (before weighting).MeasurementsMean (95% confidence interval) and median health utility' for six opioid misuse and treatment outcomes: active injection misuse; active prescription misuse; methadone maintenance therapy at initiation and when stabilized in treatment; and buprenorphine therapy at initiation and when stabilized. Utility is a numerical representation of health-related quality of life used in economic evaluations to adjust' estimated survival to include peoples' preferences for health states. Utilities are determined by surveying the general population to estimate the value they assign to particular health states on a scale where 0=the value of being dead and 1.0=the value of being in perfect health. Spouse spillover utility is assigned to a spouse of an individual who is in a particular health state.FindingsMean individual utility ranged from 0.574 [95%confidence interval (CI)=0.538, 0.611] for active injection opioid misuse to 0.766 for stabilized buprenorphine therapy (95% CI=0.738, 0.795), with other states in between. Female respondents assigned higher utility to the active prescription misuse and buprenorphine therapy at initiation states than did males (P