Clinical presentations and outcome of severe acute respiratory syndrome in children.
Clinical presentations and outcome of severe acute respiratory syndrome in children.
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DOI：
10.1016/s0140-6736(03)13364-8
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发表时间：
2003-05-17
期刊：
影响因子：
--
通讯作者：
Fok TF
中科院分区：
文献类型：
--
作者：
Hon KL;Leung CW;Cheng WT;Chan PK;Chu WC;Kwan YW;Li AM;Fong NC;Ng PC;Chiu MC;Li CK;Tam JS;Fok TF
香港受到严重急性呼吸综合征（SARS）的严重影响。家庭和医疗保健环境的接触对于传播而言很重要，使孩子处于特殊风险。然而，到目前为止，大多数数据都是针对成年人的。我们前瞻性地跟踪了在香港流行病早期阶段管理的前十个儿童。所有的孩子都与受感染的成年人密切接触。所有患者都注意到持续发烧，咳嗽，胸部和淋巴细胞减少症的进行性射线照相变化。这些儿童接受了大剂量利巴韦林，口服泼尼松龙或静脉内甲基促苯二甲甲酮的治疗，没有短期不良反应。四个青少年需要氧气疗法和两次需要的辅助通风。没有一个年幼的孩子需要补充氧气。与成人和青少年相比，SARS在年幼的孩子中似乎的临床课程似乎不那么积极。
Hong Kong has been severely affected by severe acute respiratory syndrome (SARS). Contact in households and healthcare settings is thought to be important for transmission, putting children at particular risk. Most data so far, however, have been for adults. We prospectively followed up the first ten children with SARS managed during the early phase of the epidemic in Hong Kong. All the children had been in close contact with infected adults. Persistent fever, cough, progressive radiographic changes of chest and lymphopenia were noted in all patients. The children were treated with high-dose ribavirin, oral prednisolone, or intravenous methylprednisolone, with no short-term adverse effects. Four teenagers required oxygen therapy and two needed assisted ventilation. None of the younger children required oxygen supplementation. Compared with adults and teenagers, SARS seems to have a less aggressive clinical course in younger children.
DOI：
10.1016/s0140-6736(03)13077-2
发表时间：
2003-04-19
期刊：
Lancet (London, England)
影响因子：
--
作者：
Peiris JS;Lai ST;Poon LL;Guan Y;Yam LY;Lim W;Nicholls J;Yee WK;Yan WW;Cheung MT;Cheng VC;Chan KH;Tsang DN;Yung RW;Ng TK;Yuen KY;SARS study group
通讯作者：
SARS study group
影响因子：
158.5
作者：
SMITH, DW;FRANKEL, LR;PROBER, CG
通讯作者：
PROBER, CG