Intracellular Aspects of Ganglioside Metabolism and Transport
Intracellular Aspects of Ganglioside Metabolism and Transport
复制标题
神经节苷脂代谢和运输的细胞内方面
DOI：
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发表时间：
1986
期刊：
影响因子：
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通讯作者：
R. Ghidoni
中科院分区：
文献类型：
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作者：
G. Tettamanti;A. Fiorilli;B. Venerando;S. Sonnino;R. Ghidoni
神经节苷脂是神经系统中含量特别丰富的鞘糖脂，具有高度分化的碳水化合物组成1。它们主要位于细胞质膜中，并且不对称地分布在外表面。它们的疏水部分（神经酰胺）插入膜层中，寡糖部分突出在膜表面上。细胞内区室中也存在极少量的神经节苷脂。这些神经节苷脂可能是从生物合成位点移动到质膜或从质膜迁移到降解位点的瞬时形式的表达。大多数有关神经节苷脂代谢和细胞内运输的信息都与脑神经节苷脂有关。然而，对神经外组织（如肝、脾、肾、乳腺和甲状腺）以及培养细胞（如转化细胞和肿瘤细胞）以及神经细胞原代培养物进行的研究也为该主题做出了重要贡献。
Gangliosides are glycosphingolipids particularly abundant in the nervous system and displaying a highly differentiated carbohydrate composition1. They are mainly located in the cell plasma membrane, and are asymmetrically disposed on the outer surface. Their hydrophobic portion (the ceramide) is inserted into the membrane layer and the oligosaccharide moiety protrudes on the membrane surface. Very small amounts of gangliosides are also present in intracellular compartments. These gangliosides are likely the expression of the transient forms moving from the site of biosynthesis to the plasma membrane or migrating from the plasma membrane to the site of degradation. Most of the information regarding ganglioside metabolism and intracellular transport pertains to brain gangliosides. However, important contributions to this topic were also provided by studies carried out on extraneural tissues, such as liver, spleen, kidney, mammary gland and thyroid, and on cultured cells, such as transformed and tumoral cells, and primary cultures of neural cells.