Prediabetes and the risk of cancer: a meta-analysis
Prediabetes and the risk of cancer: a meta-analysis
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DOI：
10.1007/s00125-014-3361-2
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发表时间：
2014-11-01
期刊：
影响因子：
8.2
通讯作者：
Huang, Yuli
中科院分区：
文献类型：
--
作者：
Huang, Yi;Cai, Xiaoyan;Huang, Yuli
糖尿病前期（空腹血糖受损和/或糖耐量受损）和癌症风险的前瞻性队列研究结果存在争议。我们进行了一项荟萃分析，以评估与空腹血糖受损和糖耐量异常相关的癌症风险。方法在PubMed、EMBASE和科克伦图书馆数据库中检索糖尿病前期和癌症的前瞻性队列研究数据。两名独立审查员评估了报告并提取了数据。如果前瞻性研究报告了癌症与前驱糖尿病之间相关性的校正RR及95% CI，则纳入前瞻性研究。根据终点、年龄、性别、种族、随访时间和研究特征进行亚组分析。结果来自16项前瞻性队列研究的891,426名参与者的数据。糖尿病前期与总体癌症风险增加相关（RR 1.15; 95% CI 1.06，1.23）。结果在癌症终点、年龄、随访持续时间和种族之间一致。不同定义的糖尿病前期患癌症的风险无显著差异。在一项针对特定部位的癌症分析中，糖尿病前期与胃癌/结直肠癌、肝癌、胰腺癌、乳腺癌和子宫内膜癌的风险增加显著相关（所有P
Aims/hypothesis The results from prospective cohort studies of prediabetes (impaired fasting glucose and/or impaired glucose tolerance) and risk of cancer are controversial. We conducted a meta-analysis to evaluate the risk of cancer in association with impaired fasting glucose and impaired glucose tolerance.Methods The PubMed, EMBASE and Cochrane Library databases were searched for prospective cohort studies with data on prediabetes and cancer. Two independent reviewers assessed the reports and extracted the data. Prospective studies were included if they reported adjusted RRs with 95% CIs for the association between cancer and prediabetes. Subgroup analyses were conducted according to endpoint, age, sex, ethnicity, duration of follow-up and study characteristics.Results Data from 891,426 participants were derived from 16 prospective cohort studies. Prediabetes was associated with an increased risk of cancer overall (RR 1.15; 95% CI 1.06, 1.23). The results were consistent across cancer endpoint, age, duration of follow-up and ethnicity. There was no significant difference for the risk of cancer with different definitions of prediabetes. In a site-specific cancer analysis, prediabetes was significantly associated with increased risks of cancer of the stomach/colorectum, liver, pancreas, breast and endometrium (all p