CAFFEINE ENHANCES THE SLOW-PRESSOR RESPONSE TO ANGIOTENSIN-II IN RATS - EVIDENCE FOR A CAFFEINE-ANGIOTENSIN-II INTERACTION WITH THE SYMPATHETIC NERVOUS-SYSTEM
CAFFEINE ENHANCES THE SLOW-PRESSOR RESPONSE TO ANGIOTENSIN-II IN RATS - EVIDENCE FOR A CAFFEINE-ANGIOTENSIN-II INTERACTION WITH THE SYMPATHETIC NERVOUS-SYSTEM
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DOI：
10.1172/jci113038
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发表时间：
1987-07-01
影响因子：
15.9
通讯作者：
JACKSON, EK
中科院分区：
文献类型：
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作者：
OHNISHI, A;LI, P;JACKSON, EK
本研究的目的是确定咖啡因是否增强慢性低剂量血管紧张素II（AII）输注的慢升压反应或急性AII输注的快升压反应。输注AII（125 ng/min i. p.）实验分为四组：I组：未给予咖啡因的正常大鼠（n = 9）; II组：给予咖啡因的正常大鼠（n = 9）（0.1%饮用水，n = 9）;第III组，预先用6-羟基多巴胺切除交感神经，但不用咖啡因治疗的大鼠（n = 10）; IV组：预先用6-羟多巴胺切除交感神经，并给予咖啡因治疗（n = 10）。慢性低剂量AII输注缓慢升高所有组的收缩压。咖啡因大大增强了这种慢升压反应AII在完整的动物，然而，咖啡因未能提高AII诱导的高血压交感神经切除大鼠。咖啡因预处理并没有增强急性静脉输注AII的快速升压反应。我们的结论是，咖啡因通过一种涉及交感神经系统的机制增强了慢性低剂量输注AII的慢升压效应。
The purpose of this study was to determine if caffeine augments the slow-pressor response to chronic low-dose infusions of angiotensin II (AII) or the rapid-pressor response to acute infusions of AII. AII was infused (125 ng/min i.p.) for 12 d vvia miniosmotic pumps in four groups of rats: group I, intact rats not treated with caffeine (n = 9); group II, intact rats treated with caffeine (0.1% in drinking water, n = 9); group III, rats previously sympathectomized with 6-hydroxydopamine, but not treated with caffeine (n = 10); and group IV, rats previously sympathectomized with 6-hydroxydopamine and treated with caffeine (n = 10). Chronic low-dose AII infusions slowly elevated systolic blood pressure in all groups. Caffeine greatly augmented this slow-pressor response to AII in intact animals; however, caffeine failed to enhance AII-induced hypertension in sympathectomized rats. Caffeine pretreatment did not enhance the rapid-pressor response to acute intravenous infusions of AII. We conclude that caffeine augmented the slow-pressor effect of chronic low-dose infusions of AII via a mechanism that involved the sympathetic nervous system.