Development of a Metal-Free Oxidation of Alcohols with Dimethyl Sulfoxide (DMSO) Activated by Tosyl Chloride
Development of a Metal-Free Oxidation of Alcohols with Dimethyl Sulfoxide (DMSO) Activated by Tosyl Chloride
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DOI：
10.1080/00397911.2014.916303
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发表时间：
2014-05
影响因子：
2.1
通讯作者：
F. Saadati;K. Yousefi
中科院分区：
文献类型：
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作者：
F. Saadati;K. Yousefi
在本文中，我们提出了一种在室温下使用二甲基亚砜/甲苯酰氯进行醇轻度氧化的高效无金属方法。本文描述的过程是一种简单实用的方法，可将伯、仲、烯丙醇和苯基醇氧化成相应的醛和酮。该工艺的显著优点是反应条件温和，收率和选择性好，处理简单，不含金属成分的废物少。并对相变机理进行了探讨。图形抽象
Abstract In this article we propose an efficient metal-free method for the mild oxidation of alcohols using dimethyl sulfoxide/tosyl chloride at ambient temperature. The procedure described here is an easy and practical method for the oxidation of primary, secondary, allylic, and benzylic alcohols into their corresponding aldehydes and ketones. The notable advantages of this protocol are mild reaction conditions, good yields and selectivity, and simple workup with minimal waste containing no metallic components. The mechanism of the transformation is also investigated. GRAPHICAL ABSTRACT