mtDNA polymorphisms in five French groups:: importance of regional sampling
mtDNA polymorphisms in five French groups:: importance of regional sampling
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DOI：
10.1038/sj.ejhg.5201145
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发表时间：
2004-04-01
影响因子：
5.2
通讯作者：
Mogentale-Profizi, N
中科院分区：
文献类型：
--
作者：
Dubut, V;Chollet, L;Mogentale-Profizi, N
根据经典标记，法国被报道具有地区异质性。在这里，我们建议通过分析来自五个地区的 210 名个体的 D 环和编码区多态性来测试法国线粒体基因库的同质性。获得的数据集还用于测试线粒体 DNA 检测历史上确定的混合物（在我们的例子中是英国/爱尔兰人和布列塔尼当地人之间的混合物）的能力。为此，采样程序受到特别关注，考虑到个体的地理起源和母系血统。线粒体DNA分析揭示了单倍群分布的一些区域特异性，这可以根据法国的连续定居点进行讨论。进行统计分析以调查英国、爱尔兰和法国群体内部和之间的线粒体 DNA 多样性和结构。他们倾向于表现出莫尔比昂地区与英国和爱尔兰之间的密切关系。此外，遗传证据与莫尔比昂地区是由混合事件产生的事实相符，与从英国和爱尔兰连续移民到布列塔尼的历史证据一致。这些结果还倾向于概述这样一个事实：两个地理上非常邻近的样本（莫尔比昂和菲尼斯特雷）共享文化和语言区域，可以呈现出独特的遗传模式。尽管线粒体 DNA 分析能够识别历史上报道的混合事件，但我们在此指出采样程序和代表性对迁移假设的高度影响。我们还强调区域抽样对于研究特定欧洲单倍群（此处为 U5a1a 和 U8）的传播和/或起源的重要性。
According to classical markers, France has been reported to be regionally heterogeneous. Here, we propose to test the homogeneity of the French mitochondrial gene pool by analysing D-Loop and coding regions polymorphisms in 210 individuals stemming from five regions. The data set obtained was also used to test the ability of mitochondrial DNA to detect well historically established admixtures ( admixtures between British/Irish people and native Breton people in our case). For these purposes, the sampling procedure was subject to special care, concerning the individuals' geographical origin and maternal pedigree. The mtDNA analysis revealed some regional specificities in haplogroup distribution, which is discussed in terms of successive settlements of France. Statistical analyses were conducted to investigate mtDNA diversity and structure within and between British, Irish and French groups. They tended to show affinities between Morbihan region and Britain plus Ireland. Furthermore, genetic evidences were in line with the fact that Morbihan region results from an admixture event, agreeing with historical evidences of successive migrations from Britain and Ireland into Brittany. These results also tended to outline the fact that two geographically very adjacent samples ( Morbihan and Finistere), sharing a cultural and linguistic area, can present a distinct genetic pattern. Although mtDNA analyses were able to identify a historically reported admixture event, we point out here the high influence of the sampling procedure and representativeness over the migrations hypothesis. We also underline the importance of regional sampling for studies on the spread and/or origin of specific European haplogroups ( here U5a1a and U8).