ASSOCIATION OF INSULIN-RECEPTOR SUBSTRATE-1 WITH INTEGRINS
ASSOCIATION OF INSULIN-RECEPTOR SUBSTRATE-1 WITH INTEGRINS
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DOI：
10.1126/science.7527156
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发表时间：
1994-12-02
期刊：
影响因子：
56.9
通讯作者：
RUOSLAHTI, E
中科院分区：
文献类型：
--
作者：
VUORI, K;RUOSLAHTI, E
胰岛素刺激可促进α(V)β(3)整合素(一种玻璃连素受体)与胰岛素受体底物-1(IRS-1)的结合，IRS-1是一种细胞内蛋白，通过结合其他信号分子，包括生长因子受体结合蛋白2(Grb2)和磷脂酰肌醇-3‘激酶，介导胰岛素信号转导。表达α(V)β(3)整合素的胰岛素处理细胞在玻璃连结素上的DNA合成是其他底物上的2.5倍，而表达另一种玻璃连结素受体α(V)β(5)的细胞则没有显示出这种差异。整合素与IRS-1的结合可能是生长因子与细胞外基质受体协同作用的机制之一。
Insulin stimulation was found to promote association of the alpha(v) beta(3) integrin (a vitronectin receptor) with insulin receptor substrate-1 (IRS-1), an intracellular protein that mediates insulin signaling by binding other signaling molecules, including growth factor receptor-bound protein 2 (Grb2) and phosphatidylinositol-3' kinase. Insulin-treated cells expressing the alpha(v) beta(3) integrin showed 2.5 times more DNA synthesis when plated on vitronectin than on other substrates, whereas cells expressing another vitronectin receptor, alpha(v) beta(5), did not show this difference. The association between integrin and IRS-1 may be a mechanism for the synergistic action of growth factor and extracellular matrix receptors.