Post-exposure prophylaxis after accidental prion inoculation
Post-exposure prophylaxis after accidental prion inoculation
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意外接种朊病毒后的暴露后预防
DOI：
10.1016/s0140-6736(05)78591-3
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发表时间：
1998
期刊：
影响因子：
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通讯作者：
S. Dealler
中科院分区：
文献类型：
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作者：
S. Dealler
Sir-Adriano Aguzzi和John Collinge的报告（11月22日，第1519页）1显示了预防感染是多么困难，因此可能无法说服患者这些方法的优点。我们不能忘记在小鼠和仓鼠身上进行的羊瘙痒病研究，研究表明，特定的多磺酸多苷能够减少接种物的表观大小，2有时还能防止感染的发生。因此，单剂量硫酸葡聚糖（分子量500 kD，肌肉注射400 mg/kg，毒性未知）或口服剂量的戊聚糖多硫酸酯（Norton Healthcare Ltd，Harlow，UK），400 mg，每日三次，持续3个月（人类预期寿命相当于小鼠的72小时）应考虑在人类中接种传染性海绵状脑病。戊聚糖从肠道吸收后，部分经肝、脾酶消化，24 h内大量经尿排出。戊聚糖具有8%的
Sir—Adriano Aguzzi and John Collinge’s report (Nov 22, p 1519) 1 shows how prevention of infection is difficult, and hence it may be impossible to convince the patient at risk of the advantages of these methods. We must not forget the work carried out with scrapie in mice and hamsters showing that specific polysulphonated polyglycosides were able to decrease the apparent size of the inoculum given, 2 and sometimes to prevent infection taking place. As a result, single doses of dextran sulphate (molecular weight 500 kD, 400 mg/kg intramuscularly, toxicity unknown) or oral doses of pentosan polysulphate (Norton Healthcare Ltd, Harlow, UK) as 400 mg thrice daily for 3 months (the human life expectancy equivalent of 72 h in the mouse) after transmissible spongiform encephalopathy inoculation should be considered in man. 3 About 3% of pentosan is absorbed from the gut, it is partly desulphated by liver and splenic enzymes, and then excreted largely in the urine over 24 h. Pentosan has 8% of the activity of