Cra and the control of carbon flux via metabolic pathways
Cra and the control of carbon flux via metabolic pathways
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DOI：
10.1016/0923-2508(96)84003-4
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发表时间：
1996-07-01
影响因子：
2.6
通讯作者：
Ramseier, TM
中科院分区：
文献类型：
--
作者：
Ramseier, TM
分解代谢物阻遏物-激活物（Cra）蛋白控制通过肠细菌中代谢途径的碳通量的方向。Cra与靶基因的调控区结合，对糖酵解酶和Entner-Doudoroff酶基因的表达产生负效应，而对Krebs循环、乙醛酸分流和促细胞生成酶基因的表达产生正效应。Cra介导正性Cra调控基因的环AMP非依赖性分解代谢物阻遏和负性Cra调控基因的分解代谢物激活。
The catabolite repressor-activator (Cra) protein controls the direction of carbon flux through metabolic pathways in enteric bacteria. Cra binds to the control regions of target genes and exerts a negative effect on the expression of genes encoding glycolytic and Entner-Doudoroff enzymes, while exerting a positive effect on genes encoding Krebs cycle, glyoxylate shunt and gluconeogenic enzymes. Cra mediates cyclic AMP-independent catabolite repression of positively Cra-regulated genes and catabolite activation of negatively Cra-controlled genes.