Birth weight and later risk of depression in a national birth cohort
Birth weight and later risk of depression in a national birth cohort
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DOI：
10.1192/bjp.184.1.28
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发表时间：
2004-01-01
影响因子：
10.5
通讯作者：
Martyn, CN
中科院分区：
文献类型：
--
作者：
Gale, CR;Martyn, CN
出生体重低会增加儿童行为问题的风险，目的研究出生体重与心理困扰和抑郁风险之间的关系。方法1970年英国队列研究中5187名16岁的参与者完成了12- 18岁的研究。项目一般健康问卷评估心理困扰。在26岁时，8292名参与者完成了不适清单，以评估抑郁症，并提供了有关抑郁症的历史informationsofdepression.Results妇女的出生体重小于或等于3公斤有抑郁症的风险增加，在26岁（OR=1.3; 95%CI 1.0-1.5）相比，那些体重> 3.5公斤。出生体重与报告的抑郁症史或16岁时心理困扰的风险无关。在男性中，任何测量与出生体重的全范围之间都没有关联，但是，与正常出生体重的男性相比，出生体重小于或等于2.5公斤的男性在16岁时更有可能出现心理困扰。（OR=1.6，95%CI 1.1-2.5）和26岁时报告抑郁症史（OR=1.6，95%CI 1.1-2.3）。结论胎儿期神经发育受损可能增加抑郁症的易感性。
Background Low birth weight increases the risk of childhood behavioural problems, but it is not clear whether poor foetal growth has a long-term influence on susceptibility to depression.Aims To examine the relation between birth weight and risk of psychological distress and depression.Method At age 16 years 5187 participants in the 1970 British Cohort Study completed the 12-item General Health Questionnaire to assess psychological distress. At age 26 years 8292 participants completed the Malaise Inventory to assess depression and provided information about a history of depression.Results Women whose birth weight was less than or equal to 3 kg had an increased risk of depression at age 26 years (OR=1.3; 95% CI 1.0-1.5) compared with those who weighed > 3.5 kg. Birth weight was not associated with a reported history of depression or with risk of psychological distress at age 16 years. In men there were no associations between any measurement and the full range of birth weight but, compared with men of normal birth weight, those born weighing less than or equal to 2.5 kg were more likely to be psychologically distressed at age 16 years (OR=1.6, 95% CI 1.1-2.5) and to report a history of depression at age 26 years (OR=1.6, 95% CI 1.1-2.3).Conclusions Impaired neurodevelopment during foetal life may increase susceptibility to depression.Declaration of interest None.