Physicochemical and biological characterizations of distinct strains of the transmissible mink encephalopathy agent.
Physicochemical and biological characterizations of distinct strains of the transmissible mink encephalopathy agent.
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传染性水貂脑病病原体不同菌株的物理化学和生物学特征。
DOI：
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发表时间：
1994
期刊：
影响因子：
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通讯作者：
R. Bessen
中科院分区：
文献类型：
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作者：
R. Marsh;R. Bessen
将来自威斯康星州Stetsonville的传染性水貂脑病（TME）源接种到叙利亚仓鼠中，已经鉴定出两种TME试剂菌株，其具有不同的生物学特性并产生具有不同物理化学特性的疾病特异性朊病毒蛋白（PrPTME）。尽管在英国已经鉴定出几种绵羊瘙痒病病原体菌株，但这是第一次表明在美国产生传染性海绵状脑病的病原体也能够产生不同的菌株。
Inoculation of the Stetsonville, Wisconsin source of transmissible mink encephalopathy (TME) into Syrian hamsters has identified two strains of the TME agent having distinct biological properties and producing disease-specific prion proteins (PrPTME) having different physicochemical properties. Although several strains of the sheep scrapie agent have been identified in Great Britain, this is the first indication that agents producing transmissible spongiform encephalopathies in the United States also are capable of producing distinct strains.