Ergothioneine is associated with reduced mortality and decreased risk of cardiovascular disease
Ergothioneine is associated with reduced mortality and decreased risk of cardiovascular disease
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DOI：
10.1136/heartjnl-2019-315485
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发表时间：
2020-05-01
期刊：
影响因子：
5.7
通讯作者：
Melander, Olle
中科院分区：
文献类型：
--
作者：
Smith, Einar;Ottosson, Filip;Melander, Olle
我们最近发现了一种健康意识的食物模式（HCFP）与降低心脏代谢疾病的风险有关。然而，将健康食物模式与降低心脏代谢疾病风险联系起来的分子事件尚不清楚。我们的目的是确定血浆代谢物与HCFP和测试，如果这些代谢物预测心脏代谢疾病和mortality.MethodsUsing液相色谱质谱，112血浆代谢物进行了测量，在3236名参与者没有心血管疾病（CVD）和糖尿病的人口为基础的马尔莫饮食和癌症研究。使用多变量调整线性回归，然后进行Bonferroni校正，确定与HCFP相关的代谢物。健康的饮食生物标志物随后与心脏代谢疾病的风险和死亡率在长期随访与多变量调整后的考克斯比例风险models.ResultsDuring的中位数随访时间为21.4年，603名参与者发展心血管疾病，362发展糖尿病和843名参与者死亡。五种健康饮食生物标志物与基线时的HCFP相关（p
ObjectivesWe recently identified a health conscious food pattern (HCFP) associated with reduced risk of cardiometabolic disease. However, the molecular events linking the healthy food pattern to reduced risk of cardiometabolic disease are unknown. Our aim was to identify plasma metabolites associated with the HCFP and test if such metabolites predict cardiometabolic disease and mortality.MethodsUsing liquid-chromatography mass-spectrometry, 112 plasma metabolites were measured in 3236 participants without cardiovascular disease (CVD) and diabetes mellitus from the population-based Malmo Diet and Cancer study. Metabolites associated with the HCFP were identified using multivariable adjusted linear regressions followed by Bonferroni correction. The healthy dietary biomarkers were subsequently related to risk of cardiometabolic disease and mortality during long-term follow-up with multivariable adjusted Cox proportional hazards models.ResultsDuring a median follow-up time of 21.4 years, 603 participants developed CVD, 362 developed diabetes mellitus and 843 participants died. Five healthy dietary biomarkers were associated with the HCFP at baseline (p