Computational homogenization of histological microstructures in human prostate tissue: Heterogeneity, anisotropy and tension-compression asymmetry
Computational homogenization of histological microstructures in human prostate tissue: Heterogeneity, anisotropy and tension-compression asymmetry
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DOI：
10.1002/cnm.3758
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发表时间：
2023-07-21
影响因子：
2.1
通讯作者：
Chen，Yuhang
中科院分区：
文献类型：
--
作者：
Anderson，Calum;Ntala，Chara;Chen，Yuhang
人类前列腺组织由于其多相性、异质性而表现出复杂的机械行为，具有涉及上皮隔室、腺泡腔和基质组织的分层微结构，所有这些都在复杂的网络中互连。本研究的目的是建立一个计算均匀化框架，用于量化前列腺组织的力学行为，考虑其多相异质微观结构和组织成分的力学特性。从高分辨率组织学图像重建代表性组织微结构模型。对组织成分的机械性能进行了参数研究，特别是基质组织的纤维增强超弹性，以研究其对表观组织性能的影响。然后将这些与文献中报道的实验数据进行基准测试。结果显示，前列腺组织的表观行为在结构和机械方面均具有显著的各向异性以及拉伸-压缩不对称性。还观察到与组织成分面积分数和组织结构张量等关键微观结构指标的强相关性。间质组织取向与表观性质的主要方向之间的相关性表明，间质组织在确定正常人前列腺组织中各向异性方向和压缩-张力不对称特征方面具有重要作用。这项工作提出了一种基于均质化和组织学的计算方法来表征人类前列腺或其他类似腺体组织的表观机械行为，最终目的是评估病理条件（例如，前列腺癌和良性前列腺增生）在未来的研究中可能会影响组织的机械性能。
Human prostatic tissue exhibits complex mechanical behaviour due to its multiphasic, heterogeneous nature, with hierarchical microstructures involving epithelial compartments, acinar lumens and stromal tissue all interconnected in complex networks. This study aims to establish a computational homogenization framework for quantifying the mechanical behaviour of prostate tissue, considering its multiphasic heterogeneous microstructures and the mechanical characteristics of tissue constituents. Representative tissue microstructure models were reconstructed from high‐resolution histology images. Parametric studies on the mechanical properties of the tissue constituents, particularly the fibre‐reinforced hyper‐elasticity of the stromal tissue, were carried out to investigate their effects on the apparent tissue properties. These were then benchmarked against the experimental data reported in literature. Results showed significant anisotropy, both structural and mechanical, and tension‐compression asymmetry of the apparent behaviours of the prostatic tissue. Strong correlation with the key microstructural indices such as area fractions of tissue constituents and the tissue fabric tensor was also observed. The correlation between the stromal tissue orientation and the principal directions of the apparent properties suggested an essential role of stromal tissue in determining the directions of anisotropy and the compression‐tension asymmetry characteristics in normal human prostatic tissue. This work presented a homogenization and histology‐based computational approach to characterize the apparent mechanical behaviours of human prostatic or other similar glandular tissues, with the ultimate aim of assessing how pathological conditions (e.g., prostate cancer and benign prostatic hyperplasia) could affect the tissue mechanical properties in a future study.