Antioxidant treatment may protect pancreatic beta cells through the attenuation of islet fibrosis in an animal model of type 2 diabetes
Antioxidant treatment may protect pancreatic beta cells through the attenuation of islet fibrosis in an animal model of type 2 diabetes
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DOI：
10.1016/j.bbrc.2011.09.087
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发表时间：
2011-10-22
影响因子：
3.1
通讯作者：
Song, Ki-Ho
中科院分区：
文献类型：
--
作者：
Lee, Esder;Ryu, Gyeong Ryul;Song, Ki-Ho
胰岛纤维化可能在 2 型糖尿病胰腺 β 细胞衰竭的进展中发挥重要作用。已知氧化应激通过激活胰腺星状细胞参与胰腺纤维化。然而，尚无研究调查抗氧化剂对 2 型糖尿病胰岛纤维发生的体内影响。在这项研究中，将抗氧化剂（牛磺酸或tempol）添加到大冢龙埃文斯德岛脂肪大鼠（2 型糖尿病动物模型）的饮用水中，持续 16 周。腹膜内葡萄糖耐量试验显示，注射葡萄糖后的血糖水平因抗氧化剂而降低。注射葡萄糖后，大鼠的胰岛素分泌显着减少，但抗氧化剂也使胰岛素分泌恢复。用抗氧化剂治疗的大鼠的β细胞质量和胰腺胰岛素含量高于未治疗的大鼠。抗氧化剂减弱了大鼠中的β细胞凋亡。最后，抗氧化剂显着减少了大鼠的胰岛纤维化和胰腺星状细胞的活化。我们的数据表明，抗氧化剂可以通过减轻 2 型糖尿病中的胰岛纤维化和 β 细胞凋亡来保护 β 细胞。 (C) 2011 Elsevier Inc. 保留所有权利。
Islet fibrosis could be important in the progression of pancreatic beta cell failure in type 2 diabetes. It is known that oxidative stress is involved in the pancreatic fibrosis through the activation of pancreatic stellate cells. However, no study has investigated the in vivo effects of antioxidants on islet fibrogenesis in type 2 diabetes. In this study, antioxidants (taurine or tempol) were administered in drinking water to Otsuka Long-Evans Tokushima Fatty rats, an animal model of type 2 diabetes, for 16 weeks. An intraperitoneal glucose tolerance test revealed that the blood glucose levels after the glucose injection were decreased by the antioxidants. The insulin secretion after the glucose injection, which was markedly reduced in the rats, was also restored by the antioxidants. Beta cell mass and pancreatic insulin content were greater in the rats treated with the antioxidants than in the untreated rats. Beta cell apoptosis was attenuated in the rats by the antioxidants. Finally, islet fibrosis and the activation of pancreatic stellate cells were markedly diminished in the rats by the antioxidants. Our data suggest that antioxidants may protect beta cells through the attenuation of both islet fibrosis and beta cell apoptosis in type 2 diabetes. (C) 2011 Elsevier Inc. All rights reserved.