A Nationwide Survey on the Prevalence of Dementia and Mild Cognitive Impairment in South Korea
A Nationwide Survey on the Prevalence of Dementia and Mild Cognitive Impairment in South Korea
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DOI：
10.3233/jad-2010-101221
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发表时间：
2011-01-01
影响因子：
4
通讯作者：
Cho, Maeng Je
中科院分区：
文献类型：
--
作者：
Kim, Ki Woong;Park, Joon Hyuk;Cho, Maeng Je
我们从具有代表性的韩国老年人样本中调查了痴呆症和轻度认知障碍（MCI）的患病率以及与痴呆症风险相关的因素。随机抽取8199名年龄在65岁及以上的韩国人，通过上门家访的方式，使用迷你精神状态检查（Mini-Mental State Examination）进行第一阶段筛查评估，6141名受试者（回复率= 74.9%）做出了回应。其中，2336名受试者被邀请参加痴呆和MCI II期诊断评估，有1673名受试者应答（应答率为71.6%）。诊断评估使用韩国版的《建立阿尔茨海默病评估包注册联盟》（CERAD-K）临床评估手册进行。采用CERAD-K神经心理评估量表诊断轻度认知障碍。年龄、性别、教育程度和城市标准化的痴呆患病率估计为8.1% (95% CI = 6.9-9.2)， MCI患病率为24.1% （95% CI = 21.0-27.2）。阿尔茨海默病（AD）是最常见的类型（5.7%），其次是血管性痴呆（2.0%）。MCI中遗忘型（20.1%）比非遗忘型（4.0%）更为普遍。年龄较大、男性、受教育程度较低、文盲、吸烟、头部创伤或抑郁史与痴呆症风险增加有关，饮酒和中等强度运动与痴呆症风险降低有关。我们预计，到2050年，韩国的痴呆症患者数量将每20年翻一番，预计AD在未来的痴呆症病例中所占的比例将逐渐增加。
We investigated the prevalence of dementia and mild cognitive impairment (MCI) and the factors associate with risk of dementia from a representative nationwide sample of Korean elders. 8,199 randomly-sampled Koreans aged 65 years or older were invited to participate in the Phase I screening assessment using Mini-Mental State Examination by door-to-door home visit, and 6,141 subjects (response rate = 74.9%) responded. Among them, 2,336 subjects were invited to participate in the Phase II diagnostic assessment for dementia and MCI, and 1,673 subjects responded (response rate = 71.6%). Diagnostic assessments were administered using the Korean version of the Consortium to Establish a Registry for Alzheimer's Disease Assessment Packet (CERAD-K) Clinical Assessment Battery. The CERAD-K Neuropsychological Assessment Battery was used for diagnosing MCI. Age-, gender-, education-, and urbanicity-standardized prevalence of dementia was estimated to be 8.1% (95% CI = 6.9-9.2) for overall dementia and 24.1% (95% CI = 21.0-27.2) for MCI. Alzheimer's disease (AD) was the most prevalent type (5.7%) followed by vascular dementia (2.0%). Amnestic subtype (20.1%) was much more prevalent than nonamnestic subtype in MCI (4.0%). Older age, being male, lower education level, illiteracy, smoking, and histories of head trauma or depression were associated with increased dementia risk, and alcohol use and moderately intense exercise were associated with decreased dementia risk. We expect numbers of dementia patients to double every 20 years until 2050 in Korea and expect AD to account for progressively more dementia cases in the future.