Angiopoietin-Like Protein 8/Leptin Crosstalk Influences Cardiac Mass in Youths With Cardiometabolic Risk: The BCAMS Study.
Angiopoietin-Like Protein 8/Leptin Crosstalk Influences Cardiac Mass in Youths With Cardiometabolic Risk: The BCAMS Study.
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DOI：
10.3389/fendo.2021.788549
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发表时间：
2021
影响因子：
5.2
通讯作者：
Gao S
中科院分区：
文献类型：
--
作者：
Wang D;Feng D;Wang Y;Dong P;Wang Y;Zhong L;Li B;Fu J;Xiao X;Speakman JR;Li M;Gao S
在年轻人中，过度肥胖和左心室肥厚之间的联系是多方面的，数据稀少。鉴于脂肪因子/肝因子可能影响心肌中的脂质代谢，我们旨在研究新的肝细胞因子血管生成素样蛋白8(ANGPTL8)和其他脂肪因子与心脏结构的关系，并探讨这些脂肪因子/肝因子通过脂类在多大程度上影响心脏结构。来自北京儿童和青少年代谢综合征研究(BCAMS)队列的551名参与者(年龄15-28岁)接受了超声心动图测量和抽血检测5种脂肪因子/肝因子，包括脂联素、瘦素、视黄醇结合蛋白4、成纤维细胞生长蛋白21和血管生成素8。除经典危险因素外，ANGPTL8(β=-0.68g/m2.7每z分数，P=0.015)和瘦素(β=-1.04g/m2.7每z分数，P=0.036)与左心室重量指数呈显著负相关。总胆固醇和低密度脂蛋白胆固醇显著调节ANGPTL8-LVMI关系(比例分别为19.0%和17.1%)，而甘油三酯对ANGPTL8-LVMI关系的调节作用受到瘦素水平的强烈调节，在瘦素水平较高的参与者中，甘油三酯对ANGPTL8-LVMI关系的调节作用显著占总效应的20%。调整体重指数后，其他脂肪因子/肝因子与LVMI无明显相关性。我们的发现表明，ANGPTL8，特别是与瘦素的相互作用，可能在有代谢综合征风险的年轻人的心脏重构中起到保护作用。我们的结果为心肌病的发病机制以及组织-组织串扰在这些效应中的潜在重要性提供了见解。
The link between excess adiposity and left ventricular hypertrophy is multifaceted with sparse data among youths. Given that adipokines/hepatokines may influence lipid metabolism in myocardium, we aimed to investigate the relation of the novel hepatokine angiopoietin-like protein 8 (ANGPTL8) and other adipokines with cardiac structure in a cohort of youths and explore to what extent these adipokines/hepatokines affect cardiac structure through lipids. A total of 551 participants (aged 15-28 years) from the Beijing Child and Adolescent Metabolic Syndrome Study (BCAMS) cohort underwent echocardiographic measurements plus a blood draw assayed for five adipokines/hepatokines including adiponectin, leptin, retinol binding protein 4, fibroblast growth protein 21 and ANGPTL8. Both ANGPTL8 (β = -0.68 g/m2.7 per z-score, P= 0.015) and leptin (β = -1.04 g/m2.7 per z-score, P= 0.036) were significantly inversely associated with left ventricular mass index (LVMI) independent of classical risk factors. Total cholesterol and low-density lipoprotein cholesterol significantly mediated the ANGPTL8–LVMI association (proportion: 19.0% and 17.1%, respectively), while the mediation effect of triglyceride on the ANGPTL8–LVMI relationship was strongly moderated by leptin levels, significantly accounting for 20% of the total effect among participants with higher leptin levels. Other adipokines/hepatokines showed no significant association with LVMI after adjustment for body mass index. Our findings suggest ANGPTL8, particularly interacting with leptin, might have a protective role in cardiac remodeling among youths with risk for metabolic syndrome. Our results offer insights into the pathogenesis of the cardiomyopathy and the potential importance of tissue-tissue crosstalk in these effects.
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DOI：
10.1136/bmj.e4759
发表时间：
2012-09-25
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Friedemann C;Heneghan C;Mahtani K;Thompson M;Perera R;Ward AM
通讯作者：
Ward AM
影响因子：
4.6
作者：
Chou RH;Huang PH;Hsu CY;Chang CC;Leu HB;Huang CC;Chen JW;Lin SJ
通讯作者：
Lin SJ
影响因子：
6.2
作者：
Lang, Roberto M.;Badano, Luigi P.;Voigt, Jens-Uwe
通讯作者：
Voigt, Jens-Uwe
影响因子：
6.5
作者：
Chen, Yan Q.;Pottanat, Thomas G.;Konrad, Robert J.
通讯作者：
Konrad, Robert J.
影响因子：
4.6
作者：
Fu Z;Abou-Samra AB;Zhang R
通讯作者：
Zhang R