Radial glia cells are candidate stem cells of ependymoma
Radial glia cells are candidate stem cells of ependymoma
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DOI：
10.1016/j.ccr.2005.09.001
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发表时间：
2005-10-01
期刊：
影响因子：
50.3
通讯作者：
Gilbertson, RJ
中科院分区：
文献类型：
--
作者：
Taylor, MD;Poppleton, H;Gilbertson, RJ
相同组织学类型的肿瘤通常包括临床和分子上不同的亚型；然而，这些亚型的病因尚不清楚。在这里，我们报告了组织上相同但遗传上不同的室管膜瘤表现出的基因表达模式，这些模式概括了中枢神经系统相应区域的放射状胶质细胞的基因表达模式。从室管膜瘤分离的肿瘤干细胞表现为放射状胶质细胞表型，当原位移植到小鼠体内时形成肿瘤。这些发现将受限的放射状胶质细胞群确定为室管膜瘤不同亚群的候选干细胞，并支持这一点。一种普遍的假设，认为同一组织肿瘤类型的亚群是由起源组织中不同群体的祖细胞产生的。
Tumors of the same histologic type often comprise clinically and molecularly distinct subgroups; however, the etiology of these subgroups is unknown. Here, we report that histologically identical, but genetically distinct, ependymomas exhibit patterns of gene expression that recapitulate those of radial glia cells in the corresponding region of the central nervous system. Cancer stem cells isolated from ependymomas displayed a radial glia phenotype and formed tumors when orthotopically transplanted in mice. These findings identify restricted populations of radial glia cells as candidate stem cells of the different subgroups of ependymoma, and they support. a general hypothesis that subgroups of the same histologic tumor type are generated by different populations of progenitor cells in the tissues of origin.