AN ISOFORM OF FERRITIN AS A COMPONENT OF PROTEIN YOLK PLATELETS IN SCHISTOSOMA-MANSONI
AN ISOFORM OF FERRITIN AS A COMPONENT OF PROTEIN YOLK PLATELETS IN SCHISTOSOMA-MANSONI
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DOI：
10.1002/mrd.1080410307
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发表时间：
1995-07-01
影响因子：
2.5
通讯作者：
KUNZ, W
中科院分区：
文献类型：
--
作者：
SCHUSSLER, P;POTTERS, E;KUNZ, W
曼氏血吸虫具有两种铁储存蛋白铁蛋白的同种型，Fer 1和Fer 2。在mRNA水平和蛋白质水平上，Fer 1比Fer 2丰富得多;雌性含有的Fer 1比雄性多15倍。相比之下，几乎等量的Fer 2在两性中出现。通过电子显微镜，我们确定了铁蛋白的电子致密膜结合体的细胞中的卵黄。这些包涵体的形成模式（从电子显微镜推断）和丰富的磷脂多层膜表明，这些机构是一个溶酶体的性质。在这里，我们解释这些含铁蛋白的夹杂物蛋白蛋黄血小板。迄今为止，大多数文献都没有包含任何关于吸虫中存在蛋白卵黄的暗示。铁蛋白在胚胎发育中的可能功能进行了讨论。(C)1995年Wiley-Liss，Inc.
Schistosoma mansoni possesses two isoforms of the iron storage protein ferritin, Fer1 and Fer2. At the mRNA level as well as at the protein level, Fer1 is much more abundant than Fer2; females contain an about 15-fold excess of Fer1 compared with males. in contrast, nearly equal amounts of Fer2 occur in both sexes. By electron microscopy we identified ferritin as a component of electron dense membrane-bound bodies in cells of the vitellarium. The mode of formation of these inclusions (as inferred from electron microscopy) and the abundance of phospholipid multilayered membranes suggest that these bodies are of a lysosomal nature. Here we interpret these ferritin-containing inclusions as protein yolk platelets. To date, most of the literature does not contain any hints of the existence of protein yolk in trematodes. The possible function of ferritin in embryonic development is discussed. (C) 1995 Wiley-Liss, Inc.