Discussion of Research Priorities for Gait Disorders in Parkinson's Disease.

Discussion of Research Priorities for Gait Disorders in Parkinson's Disease.
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帕金森病步态障碍研究重点探讨。

DOI:
10.1002/mds.28883
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发表时间:
2022-02
期刊:
影响因子:
8.6
通讯作者:
Papa, Stella M.
Papa, Stella M.
中科院分区:
医学1区
文献类型:
--
作者:
Bohnen, Nicolaas, I;Costa, Rui M.;Dauer, William T.;Factor, Stewart A.;Giladi, Nir;Hallett, Mark;Lewis, Simon J. G.;Nieuwboer, Alice;Nutt, John G.;Takakusaki, Kaoru;Kang, Un Jung;Przedborski, Serge;Papa, Stella M.

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步态和平衡异常在帕金森病中常见,是最致残的运动症状之一,对多巴胺能或其他治疗(包括深部脑刺激)无效。由于对这些复杂疾病的了解有限,开发有效疗法的努力受到了挑战。迫切需要新颖的、有针对性的研究来加快这一领域的进展。国际帕金森氏症和运动障碍学会科学问题委员会已责成该领域的一个专家小组考虑目前的知识差距,并确定最有可能产生突破性数据的研究路线。
Gait and balance abnormalities develop commonly in Parkinson’s disease and are among the motor symptoms most disabling and refractory to dopaminergic or other treatments, including deep brain stimulation. Efforts to develop effective therapies are challenged by limited understanding of these complex disorders. There is a major need for novel and appropriately targeted research to expedite progress in this area. The Scientific Issues Committee of the International Parkinson and Movement Disorder Society has charged a panel of experts in the field to consider the current knowledge gaps and determine the research routes with highest potential to generate groundbreaking data.
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