Luotonin A: A Lead toward Anti-Cancer Agent Development
Luotonin A: A Lead toward Anti-Cancer Agent Development
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DOI：
10.3987/rev-05-599
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发表时间：
2005-09
期刊：
影响因子：
0.6
通讯作者：
Zhongze Ma;Y. Hano;T. Nomura
中科院分区：
文献类型：
--
作者：
Zhongze Ma;Y. Hano;T. Nomura
Luotonin A, a novel pyrroloquinazolinoquinoline alkaloid isolated from the aerial parts of Peganum nigellastrum Bunge, showed a cytotoxic activity against mouse leukemia cells (P-388) and an inhibitory activity against topoisomerase I and II. This review covers the isolation, structural determination, synthesis and biological activity of luotonin A and its related derivatives. A water-soluble topoisomerase I inhibitor, 14-azacamptothecin analogous to luotonin A and camptothecin, was also discussed.
