Pathogenicity of Australian strains of avian infectious bronchitis virus
Pathogenicity of Australian strains of avian infectious bronchitis virus
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DOI：
10.1053/jcpa.2001.0528
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发表时间：
2002-02-01
影响因子：
0.8
通讯作者：
Hooper, P
中科院分区：
文献类型：
--
作者：
Ignjatovic, J;Ashton, DF;Hooper, P
比较了1961年至1994年从澳大利亚分离的25株传染性支气管炎病毒(IBV)对白来航鸡的致病性。12株为肾病致病株，10株为呼吸道致病株，其余3株为混合致病株。经鉴定，该IBV毒株为肾病所致的临床肾炎、大体和组织学肾损害，死亡率为5-90%。根据这些特征的严重程度，可将肾脏致病菌株进一步细分为高、中、低致病力菌株。三株混合致病株均可引起气管炎、轻度临床肾炎和肾脏病变，但无死亡病例。这10种呼吸机菌株引起了气管的组织学损伤，但对肾脏没有影响。且未诱发临床肾炎或死亡。在1961至1976年间分离的12株IBV中，有9株是肾脏致病株，死亡率为15%-90%。相比之下。在1981至1994年间分离的13株毒株中，只有3株是肾脏致病株，死亡率为5-37%，而9株是呼吸道毒株。与其他呼吸道毒株不同，这九种毒株中有七种完全无法在肾脏复制。结果表明，IBV流行毒株从高致病性(20世纪60年代至70年代)转变为呼吸型(80年代至90年代初)，此外，80年代末出现了组织趋向性改变的呼吸道毒株。(C)2002年爱思唯尔科学有限公司。
The pathogenicity of 25 strains of infectious bronchitis virus (IBV) isolated in Australia between 1961 and 1994 was compared in white leghorn specific pathogen-free chicks. Twelve strains were nephropathogenic and 10 respiratory, the other three being of mixed pathogenicity. The IBV strains, identified as nephropathogenic induced clinical nephritis, gross and histological kidney lesions, and mortality of 5-90%. According to the severity of these features, the nephropathogenic strains could be further subdivided into strains of high, moderate or low pathogenicity. The three strains of mixed pathogenicity induced tracheitis, mild clinical nephritis and kidney lesions but no mortality. The 10 respirator,, strains caused histological lesions in the trachea but not in the kidney. and did not induce clinical nephritis or mortality. Of 12 IBV strains isolated between 1961 and 1976, nine were nephropathogenic, inducing mortality of 15-90%. In contrast. of 13 strains isolated between 1981 and 1994, only three were nephropathogenic, inducing mortality of 5-37%, whereas nine were respiratory. Seven of these nine strains, unlike other respiratory strains, failed completely to replicate in the kidney. The results indicated a change in the prevalent IBV strains from highly nephropathogenic (1960s to 1970s) to respiratory (1980s to early 1990s) moreover, the late 1980s saw the emergence of respiratory strains with altered tissue tropism. (C) 2002 Elsevier Science Ltd.