Dr William Coley and tumour regression: a place in history or in the future.
Dr William Coley and tumour regression: a place in history or in the future.
复制标题
DOI：
10.1093/postgradmedj/79.938.672
复制
发表时间：
2003-12
影响因子：
5.1
通讯作者：
S. H. Hoption Cann;J. P. van Netten;C. van Netten
中科院分区：
文献类型：
--
作者：
S. H. Hoption Cann;J. P. van Netten;C. van Netten
自发性肿瘤消退发生在细菌、真菌、病毒和原生动物感染之后。这种现象激发了许多基本癌症免疫疗法的发展，其历史跨越数千年。Coley利用这种自然现象，在19世纪末开发了一种杀死癌症的细菌疫苗。他观察到，诱导发烧对肿瘤消退至关重要。不幸的是，目前很少有人相信发热反应可以对抗感染，甚至癌症。快速生长的肿瘤含有大量的白细胞。这些细胞在防御和修复中发挥作用;然而，修复功能也可以支持肿瘤生长。肿瘤内感染可能重新激活防御功能，导致肿瘤消退。几个世纪以来，这种免疫疗法被反复“重新发现”，这可能是一种巧合吗？显然，科利的癌症治疗方法在过去、现在和未来都有一席之地。它为开发广泛适用、相对便宜但有效的癌症治疗方法提供了难得的机会。即使在常规治疗无法达到的情况下，也有希望。
Spontaneous tumour regression has followed bacterial, fungal, viral, and protozoal infections. This phenomenon inspired the development of numerous rudimentary cancer immunotherapies, with a history spanning thousands of years. Coley took advantage of this natural phenomenon, developing a killed bacterial vaccine for cancer in the late 1800s. He observed that inducing a fever was crucial for tumour regression. Unfortunately, at the present time little credence is given to the febrile response in fighting infections-no less cancer. Rapidly growing tumours contain large numbers of leucocytes. These cells play a part in both defence and repair; however, reparative functions can also support tumour growth. Intratumoural infections may reactivate defensive functions, causing tumour regression. Can it be a coincidence that this method of immunotherapy has been "rediscovered" repeatedly throughout the centuries? Clearly, Coley's approach to cancer treatment has a place in the past, present, and future. It offers a rare opportunity for the development of a broadly applicable, relatively inexpensive, yet effective treatment for cancer. Even in cases beyond the reach of conventional therapy, there is hope.