Relationship between Memory Performance and β-Amyloid Deposition at Different Stages of Alzheimer's Disease
Relationship between Memory Performance and β-Amyloid Deposition at Different Stages of Alzheimer's Disease
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DOI：
10.1159/000334295
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发表时间：
2012-01-01
影响因子：
3
通讯作者：
Rowe, Christopher C.
中科院分区：
文献类型：
--
作者：
Chetelat, Gael;Villemagne, Victor L.;Rowe, Christopher C.
背景：尸检研究表明，β-淀粉样蛋白(Aβ)沉积与阿尔茨海默病(AD)认知损害的程度只有微弱的关系。用于活体PET成像的Aβ配体的发展极大地促进了对这一问题的评估。目的：本研究的目的是提供关于Aβ沉积与非痴呆老年人和轻度认知障碍或AD患者的情景记忆缺陷之间关系的现有知识的概述。方法：通过比较高匹兹堡化合物B(PIB)和低匹兹堡化合物B(PIB)个体的记忆表现，以及将记忆表现与PIB保持作为一个连续变量进行相关性分析的研究，获得信息。结果：先前评估记忆和大脑皮层PIB之间关系的研究报道了相互矛盾的发现，总体上表明这种联系很弱，可能是间接的，而且只能在早期阶段被检测到。评估与局域性而不是全局性新皮质PIB的关系，我们发现在疾病的痴呆前期，情景记忆缺陷和新皮质临时PIB之间存在特定的关系，这种关系独立于海马体萎缩。结论：阿尔茨海默病症状前阶段局部Aβ沉积与情景记忆障碍有关。版权所有(C)2012 S.Karger AG，巴塞尔
Background: Postmortem studies have suggested that beta-amyloid (A beta) deposition was only weakly related to the degree of cognitive impairment in Alzheimer's disease (AD). The development of A beta ligands for in vivo PET imaging has greatly facilitated the assessment of this question. Objective: The objective of the present study was to provide an overview of our current knowledge regarding the relationship between A beta deposition and episodic memory deficits in nondemented elderly and in patients with mild cognitive impairment or AD. Methods: Information was obtained both from studies comparing memory performance in individuals with high Pittsburgh compound B (PiB) and those with low PiB and from studies performing correlation analyses between memory performance and PiB retention considered as a continuous variable. Results: Previous studies assessing the relationship between memory and global neocortical PiB reported conflicting findings, and overall suggest that this link is weak, probably indirect, and detectable only in early stages. Assessing the relationship with regional instead of global neocortical PiB, we found a specific relationship between episodic memory deficits and neocortical temporal PiB, independent from hippocampal atrophy, in the predementia stage of the disease. Conclusion: There is a relationship between regional A beta deposition and episodic memory deficits in the presymptomatic stage of AD. Copyright (C) 2012 S. Karger AG, Basel