Enriched environment experience overcomes the memory deficits and depressive-like behavior induced by early life stress
Enriched environment experience overcomes the memory deficits and depressive-like behavior induced by early life stress
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DOI：
10.1016/j.neulet.2006.05.048
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发表时间：
2006-08-14
影响因子：
2.5
通讯作者：
Cao, Jun
中科院分区：
文献类型：
--
作者：
Cui, Minghu;Yang, Ya;Cao, Jun
早期生活中的压力被认为会导致认知和情感障碍，并破坏从青春期到成年的海马突触可塑性，但目前尚不清楚暴露于富集环境（EE）是否能克服这些影响。在这里，我们报道了在出生后2-21天，将大鼠饲养在筑巢/床上材料有限的笼子中，体重增加减少，这种早期生活压力损害了莫里斯水迷宫的空间学习和记忆，并增加了年轻成年大鼠（出生后53-57天）的强迫游泳测试的抑郁样行为。早期生活压力对成年大鼠海马ca1区长时程增强也有影响。值得注意的是，出生后22-52天的情感表达体验对空间学习/记忆和抑郁样行为没有影响，但它显著促进了对照大鼠的UP，并完全克服了早期生活应激对青年成年大鼠的影响。这些发现表明，情感表达经验可能有助于临床干预，预防发育过程中的认知和情感障碍。2006爱思唯尔爱尔兰有限公司版权所有。
Stress in early life is believed to cause cognitive and affective disorders, and to disrupt hippocampal synaptic plasticity in adolescence into adult, but it is unclear whether exposure to enriched environment (EE) can overcome these effects. Here, we reported that housing rats in cages with limited nesting/bedding materials on postnatal days 2-21 reduced body weight gain, and this type of early life stress impaired spatial learning and memory of the Morris water maze and increased depressive-like behavior of the forced swim test in young adult rats (postnatal days 53-57). Early life stress also impaired long-term potentiation in hippocampal CA I area of slices of young adult rats. Remarkably, EE experience on postnatal days 22-52 had no effect on spatial learning/memory and depressive-like behavior, but it significantly facilitated UP in control rats, and completely overcame the effects of early life stress on young adult rats. These findings suggest that EE experience may be useful for clinical intervention in preventing cognitive and affective disorders during development. (c) 2006 Elsevier Ireland Ltd. All rights reserved.