Enantioselective Rh-catalyzed hydrogenation of 3-aryl-2-phosphonomethylpropenoates by a new class of chiral ferrocenyl diphosphine ligands.
Enantioselective Rh-catalyzed hydrogenation of 3-aryl-2-phosphonomethylpropenoates by a new class of chiral ferrocenyl diphosphine ligands.
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DOI：
10.1021/ol9012469
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发表时间：
2009-08
期刊：
影响因子：
5.2
通讯作者：
Dao‐Yong Wang;Xiangping Hu;C. Hou;Jun Deng;Sai-Bo Yu;Zheng-chao Duan;Jia-Di Huang;Zhuo Zheng
中科院分区：
文献类型：
--
作者：
Dao‐Yong Wang;Xiangping Hu;C. Hou;Jun Deng;Sai-Bo Yu;Zheng-chao Duan;Jia-Di Huang;Zhuo Zheng
A new class of chiral ferrocenyl diphosphine ligands with an imidazole ring, (R(c),S(Fc))-ImiFerroPhos, has been prepared from acylferrocenes through a five-step transformation and successfully applied in the Rh-catalyzed asymmetric hydrogenation of various 3-aryl-substituted 2-phosphonomethylpropenoates, in which a series of chiral 3-phosphono-2-arylmethylpropanoic acid derivatives were achieved in ee values of up to 98%.
