VENOUS THROMBOEMBOLISM PROPHYLAXIS IN GYNECOLOGIC ONCOLOGY - A PROSPECTIVE, CONTROLLED TRIAL OF LOW-DOSE HEPARIN
VENOUS THROMBOEMBOLISM PROPHYLAXIS IN GYNECOLOGIC ONCOLOGY - A PROSPECTIVE, CONTROLLED TRIAL OF LOW-DOSE HEPARIN
复制标题
DOI：
10.1016/0002-9378(83)91205-x
复制
发表时间：
1983-01-01
影响因子：
9.8
通讯作者：
CREASMAN, WT
中科院分区：
文献类型：
--
作者：
CLARKEPEARSON, DL;COLEMAN, RE;CREASMAN, WT
接受妇科恶性肿瘤手术的患者[185]参加了一项低剂量肝素预防的随机对照试验。通过每日腿部纤维蛋白原125I计数和阻抗体积描记法对深静脉血栓形成进行前瞻性监测。对照组97例患者中的12例（12.4%）和低剂量肝素组88例患者中的13例（14.8%）发生静脉血栓栓塞并发症。对照组和低剂量肝素组之间近端深血栓形成、小腿静脉血栓形成或肺栓塞的发生率无统计学差异。低剂量肝素对因妇科恶性肿瘤接受盆腔大手术的患者没有任何预防益处。
Patients undergoing operation for gynecologic malignancy [185] participated in a randomized controlled trial of low-dose heparin prophylaxis. Prospective surveillance for deep venous thrombosis was performed with daily fibrinogen 125I counting in the legs and impedance plethysmography. Twelve of 97 (12.4%) patients in the control group and 13 of 88 (14.8%) patients in the low-dose heparin group developed a venous thromboembolic complication. There was no statistical difference in the incidence of proximal deep thrombosis, calf vein thrombosis or pulmonary emboli between the control and low-dose heparin groups. Low-dose heparin does not afford any prophylactic benefit to patients undergoing major pelvic operative procedures for gynecologic malignancy.