Carcinogenicity of shift-work, painting, and fire-fighting
Carcinogenicity of shift-work, painting, and fire-fighting
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DOI：
10.1016/s1470-2045(07)70373-x
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发表时间：
2007-12-01
期刊：
影响因子：
51.1
通讯作者：
Cogliano, Vincent
中科院分区：
文献类型：
--
作者：
Straif, Kurt;Baan, Robert;Cogliano, Vincent
大多数关于画家的细胞遗传学研究报告了遗传损伤水平的增加，如染色体畸变、微核形成、姐妹染色单体交换、23和DNA单链断裂。几项研究表明，剂量反应与工作时间有关。吸烟状况的分层分析一般显示吸烟者和非吸烟者的结果相似。该工作组得出结论，“有足够的证据表明，作为画家的职业接触会导致肺癌和膀胱癌”。此外，“在人类中有有限的证据”，主要是基于对母亲接触绘画的研究，表明绘画与儿童白血病有关。总的来说，作为油漆工的职业暴露是“对人类致癌的”（第1组）。15消防员暴露于许多有毒的燃烧产物，包括许多已知的、可能的或可能的致癌物质。这些间歇性接触可能是强烈的，短期接触可释放颗粒物和一些致癌物，特别是苯、苯并[a]芘、1,3 -丁二烯和甲醛，可能会很高。
Most cytogenetic studies on painters reported increased levels of genetic damage, such as chromosomal aberrations, micronucleus formation, sister chromatid exchange, 23 and DNA single-strand breaks. Several studies showed a dose-response association with duration of work. Stratified analyses by tobacco-smoking status generally showed similar results in smokers and non-smokers. The Working Group concluded that there is “sufficient evidence in humans that occupational exposure as a painter causes cancers of the lung and urinary bladder”. Additionally, there is “limited evidence in humans”, mainly on the basis of studies of maternal exposure, that painting is associated with child hood leukaemia. Overall, occupational exposure as a painter is “carcinogenic to humans”(Group 1). 15Firefighters are exposed to many toxic combustion products, including many known, probable or poss ible carcin ogens. These intermittent expo sures can be intense, and shortterm exposures can be high for resp ir able particulate matter and for some carcinogens, notably benzene, benzo [a] pyrene, 1, 3-butadiene, and formaldehyde.