Infection of human B lymphoma cells by Mycoplasma fermentans induces interaction of its elongation factor with the intracytoplasmic domain of Epstein-Barr virus receptor (gp140, EBV/C3dR, CR2, CD21)
Infection of human B lymphoma cells by Mycoplasma fermentans induces interaction of its elongation factor with the intracytoplasmic domain of Epstein-Barr virus receptor (gp140, EBV/C3dR, CR2, CD21)
复制标题
DOI：
10.1016/j.femsle.2005.06.052
复制
发表时间：
2005-08-15
影响因子：
2.1
通讯作者：
Frade, R
中科院分区：
文献类型：
--
作者：
Balbo, M;Barel, M;Frade, R
人类细胞系经常被支原体菌株感染。我们已经证明，当被发酵支原体感染时，人B淋巴瘤细胞增殖强烈增加。这些感染的B细胞表达p45 kDa蛋白，其与CD 21的细胞内结构域（EBV/C3 d受体）相互作用。p45分析表明，这是一个新的基因，它编码一种源自发酵支原体的延伸因子。p45与CD 21的相互作用是特异性的，与CD 19没有相互作用。这是发酵支原体在感染人B细胞时产生与参与B细胞增殖的CD 21相互作用的p45支原体组分的首次证明。(c)2005年，欧洲微生物学会联合会。Elsevier B. V.出版，保留所有权利。
Human cell lines are often infected by mycoplama strains. We have demonstrated that when infected by Mycoplasma fermentans, human B lymphoma cell proliferation increased strongly. These infected B cells expressed a p45 kDa protein which interacted with the intracellular domain of CD21, the EBV/C3d receptor. p45 analysis demonstrated that this is a new gene which encodes an elongation factor originating from Mycoplasma fermentans. p45 interaction with CD21 was specific, there being no interaction with CD19. This is the first demonstration that Mycoplasma fermentans, in infecting human B cells, generates a p45 Mycoplasma component that interacts with CD21, which is involved in B cell proliferation. (c) 2005 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.