Self-assembled antibacterial coating by N-halamine polyelectrolytes on a cellulose substrate
Self-assembled antibacterial coating by N-halamine polyelectrolytes on a cellulose substrate
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DOI：
10.1039/c4tb01699h
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发表时间：
2015-01-01
影响因子：
7
通讯作者：
Huang, T. S.
中科院分区：
文献类型：
--
作者：
Liu, Ying;Li, Jing;Huang, T. S.
在这项研究中，成功合成了两种N-卤胺聚合物前体，即阳离子均聚物聚（（3-丙烯酰胺基丙基）三甲基氯化铵）（CHP）和阴离子均聚物聚（2-丙烯酰胺基-2-甲基丙磺酸钠盐）（AHP），并通过逐层（LbL）沉积技术涂覆在棉织物上。采用扫描电子显微镜、X射线光电子能谱和傅里叶变换红外光谱对涂层棉织物进行了表征。评价了未涂层和涂层棉织物对金黄色葡萄球菌和大肠杆菌的杀菌效果。氯化样本（CHP-Cl和AHP-Cl）灭活100% S。aureus和99.73% E. coliO 157：H7，经相当于50次机洗后，仍有51%以上的氯保留。皮肤刺激试验表明，CHP-Cl和AHP-Cl化合物对家兔皮肤无刺激性，因此这些样品可能用于未来的生物医学应用。作为一种简单有效的织物涂层方法，LbL沉积技术可以拓宽N-卤胺杀菌剂在其他极性物质中作为抗菌功能涂层的应用。
In this research, two N-halamine polymer precursors, a cationic homopolymer poly((3-acrylamidopropyl) trimethylammonium chloride) (CHP) and an anionic homopolymer poly(2-acrylamido-2-methylpropane sulfonic acid sodium salt) (AHP), have been successfully synthesized and coated onto cotton fabrics via a layer-by-layer (LbL) deposition technique. The coated cotton fabrics were characterized using scanning electron microscopy, X-ray photoelectron spectroscopy, and Fourier transform infrared spectroscopy. The biocidal efficacies of uncoated and coated cotton fabrics were evaluated against Staphylococcus aureus and Escherichia coli. The chlorinated swatches (CHP-Cl and AHP-Cl) inactivated 100% S. aureus and 99.73% E. coli O157:H7 in 30 min. Over 51% of the chlorine is retained after the equivalent of 50 machine washes. A skin stimulation test showed that CHP-Cl and AHP-Cl compounds have no irritation to rabbit skin, and so these swatches might be utilized for biomedical applications in the future. As an easy and efficient way of coating fabrics, the LbL deposition technique can broaden the use of N-halamine biocides in other polar substances as antimicrobial functional coatings.