Gene conversions in genes encoding outer-membrane proteins in H-pylori and C-pneumoniae
Gene conversions in genes encoding outer-membrane proteins in H-pylori and C-pneumoniae
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DOI：
10.1016/s0168-9525(00)02151-x
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发表时间：
2001-01-01
影响因子：
11.4
通讯作者：
Koonin, EV
中科院分区：
文献类型：
--
作者：
Jordan, IK;Makarova, KS;Koonin, EV
幽门螺杆菌和肺炎衣原体都对人类具有致病性。它们的基因组最近已经完成，可以详细研究它们的进化和组织。在这里，我们描述了一个进化分析的H。pylori和C. pneumoniae的基因编码它们的外膜蛋白。通过比较两个H. pylori菌株和2株C.肺炎菌株，我们确定了这些基因之间的多个独立的转换。这种重组事件可能为这些细菌病原体提供选择性优势。
Helicobacter pylori and Chlamydia pneumoniae are both pathogenic to humans. Their genomes have recently been completed, allowing detailed study of their evolution and organization. Here we describe an evolutionary analysis of the H. pylori and C. pneumoniae genes that encode their outer-membrane proteins. By comparing complete genome sequences of two H. pylori strains and two C. pneumoniae strains, we identify multiple independent conversions among these genes. Such recombination events might provide a selective advantage for these bacterial pathogens.