Differential susceptibility in spillover between interparental conflict and maternal parenting practices: evidence for OXTR and 5-HTT genes.
Differential susceptibility in spillover between interparental conflict and maternal parenting practices: evidence for OXTR and 5-HTT genes.
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父母间冲突和母亲养育方式之间溢出效应的不同易感性：OXTR 和 5-HTT 基因的证据。
DOI：
10.1037/a0028302
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Suor,JenniferH
中科院分区：
文献类型：
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作者：
Sturge-Apple,MelissaL;Cicchetti,Dante;Davies,PatrickT;Suor,JenniferH
在情感溢出假说和对环境影响框架的不同易感性的指导下，本研究考察了5-羟色胺转运体(5-HTT)和催产素受体(OXTR)基因如何调节父母间冲突与母亲养育方式之间的关联。201名母亲和她们2岁的孩子参加了一项基于实验室的研究评估。结果支持溢出框架内的不同易感性假说。关于OXTRrs53576，具有GG基因的母亲在不同程度的父母间冲突中表现出更大的母体敏感性差异。携带一个或两个5-HTTLPR S等位基因的母亲表现出对敏感和严厉/惩罚性照顾行为的不同易感性。最后，分析检查了母亲的抑郁症状和对孩子的情感亲密度是否起到了调节作用。研究结果表明，母亲与孩子的情感亲密间接地将OXTR与母亲的敏感性联系在一起。这些结果突出了分子遗传学如何解释溢出模型中的异质性，并对特定的育儿行为产生不同的影响。与婚姻痛苦的父母一起工作的临床医生和治疗师的含义被讨论。
Guided by the affective spillover hypothesis and the differential susceptibility to environmental influence frameworks, the present study examined how associations between interparental conflict and mothers' parenting practices were moderated by serotonin transporter (5-HTT) and oxytocin receptor (OXTR) genes. A sample of 201 mothers and their 2-year old child participated in a laboratory-based research assessment. Results supported differential susceptibility hypotheses within spillover frameworks. With respect to OXTR rs53576, mothers with the GG genotype showed greater differential maternal sensitivity across varying levels of interparental conflict. Mothers with one or two copies of the 5-HTTLPR S allele demonstrated differential susceptibility for both sensitive and harsh/punitive caregiving behaviors. Finally, analyses examined whether maternal depressive symptoms and emotional closeness to their child mediated the moderating effects. Findings suggest that maternal emotional closeness with their child indirectly linked OXTR with maternal sensitivity. The results highlight how molecular genetics may explain heterogeneity in spillover models with differential implications for specific parenting behaviors. Implications for clinicians and therapists working with maritally distressed parents are discussed.