T-cell and NK-cell infiltration into solid tumors: a key limiting factor for efficacious cancer immunotherapy.
T-cell and NK-cell infiltration into solid tumors: a key limiting factor for efficacious cancer immunotherapy.
复制标题
T细胞和NK细胞浸润到实体瘤中：有效的癌症免疫疗法的关键限制因素。
DOI：
10.1158/2159-8290.cd-13-0985
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发表时间：
2014-05
期刊：
影响因子：
28.2
通讯作者：
Coukos G
中科院分区：
文献类型：
--
作者：
Melero I;Rouzaut A;Motz GT;Coukos G
癌症免疫治疗具有很大的前景，但受到肿瘤用于防止持续抗肿瘤免疫应答的多种机制的限制。肿瘤通过可溶性和细胞表面介质、脉管系统和免疫抑制细胞（如骨髓源性抑制细胞和调节性T细胞）破坏抗原呈递、T/NK细胞活化和T/NK细胞归巢。然而，许多阻止抗肿瘤免疫效力的分子机制已经被鉴定，并且可以被联合免疫疗法破坏。在这里，我们研究了肿瘤利用的免疫抑制机制，并提供了正在开发的治疗方法的见解，以克服它们，重点是淋巴细胞运输。
Cancer immunotherapy has great promise, but is limited by diverse mechanisms used by tumors to prevent sustained antitumor immune responses. Tumors disrupt antigen presentation, T/NK–cell activation, and T/NK–cell homing through soluble and cell-surface mediators, the vasculature, and immunosuppressive cells such as myeloid-derived suppressor cells and regulatory T cells. However, many molecular mechanisms preventing the efficacy of antitumor immunity have been identified and can be disrupted by combination immunotherapy. Here, we examine immunosuppressive mechanisms exploited by tumors and provide insights into the therapies under development to overcome them, focusing on lymphocyte traffic.