Dietary fatty acids and human breast cancer cell growth, invasion, and metastasis.
Dietary fatty acids and human breast cancer cell growth, invasion, and metastasis.
复制标题
膳食脂肪酸与人乳腺癌细胞的生长、侵袭和转移。
DOI：
10.1007/978-1-4615-2510-3_8
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发表时间：
1994
影响因子：
--
通讯作者：
Liu,XH
中科院分区：
文献类型：
--
作者：
Rose,DP;Connolly,JM;Liu,XH
人们对利用低脂饮食干预来降低具有潜在可治愈疾病的术后乳腺癌患者的复发风险有相当大的兴趣。1 - 5这一概念最初是从流行病学和临床研究中发展起来的，在其他地方进行了综述，5- 6但它得到了利用实验动物模型的研究的支持。其中最突出的是埃里克森及其同事的工作，他们表明，与含有相同脂肪但LA含量低的饮食相比，喂食富含亚油酸（LA）的高脂肪饮食，一种omega-6多不饱和脂肪酸，增强了小鼠乳腺肿瘤细胞系的转移。Katz和Boylan 8用可移植的转移性大鼠乳腺癌获得了类似的结果，但饮食中含有20%或5%（wt/wt）的玉米油，一种富含LA的脂质来源。
There is considerable interest in the utilization of a low-fat dietary intervention to reduce the risk of recurrence in postsurgical breast cancer patients with potentially curable disease.1-5This concept developed initially from epidemiological and clinical studies, reviewed elsewhere,5-6but it gained support from investigations utilizing experimental animal models. Prominent among these was the work of Erickson and colleagues, who showed that feeding a high-fat diet rich in linoleic acid (LA), an omega-6 polyunsaturated fatty acid, enhanced metastasis of a mouse mammary tumor cell line, compared with a diet containing the same {tiyquantity} of fat, but low in LA content. Similar results were obtained by Katz and Boylan8with a transplantable, metastasizing, rat mammary carcinoma, but with diets containing either 20% or 5% (wt/wt) corn oil, a lipid source rich in LA.