Hematological Indices of Sickle Cell Anaemia Patients with Pulmonary Tuberculosis in Northern Nigeria
Hematological Indices of Sickle Cell Anaemia Patients with Pulmonary Tuberculosis in Northern Nigeria
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DOI：
10.4084/mmid.2010.014
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发表时间：
2010-01-01
影响因子：
3.2
通讯作者：
Jolayemi, Bashir
中科院分区：
文献类型：
--
作者：
Ahmed, Sagir G.;Bukar, Audu A.;Jolayemi, Bashir
尼日利亚结核病发病率居世界第四位，镰状细胞贫血发病率居世界第一位。SCA患者的免疫力受损，容易感染结核病。因此，我们研究了尼日利亚SCA结核病患者的血液学指标。共23例SCA合并TB患者与相同数量的年龄和性别匹配的SCA非TB患者进行了平行研究。与非TB患者相比，SCA伴TB患者的红细胞压积显著降低，循环镰状细胞（CSC）水平升高，网织红细胞计数水平相似。与未患TB的SCA患者相比，患有TB的SCA患者的平均WBC计数显著更高，与更高的嗜中性粒细胞频率相关。单核细胞和嗜酸性粒细胞减少仅见于SCA合并TB患者，频率分别为52%和65%。淋巴细胞和嗜碱性粒细胞计数正常，所有患者和非结核病。两组患者的平均血小板计数均较高，但TB患者的血小板增多频率显著较高。SCA合并TB患者的平均ESR显著高于无感染的患者。本研究结果显示，SCA患者的TB与CSC水平升高、红细胞压积水平下降、次优网织红细胞增多、嗜中性粒细胞增多、单核细胞增多、血小板增多、嗜酸性粒细胞减少和ESR水平升高相关。因此，SCA患者表现出这些血液学指标，应调查结核病。
Nigeria has the fourth highest prevalence of TB and the highest prevalence of Sickle cell anaemia (SCA) in the world. SCA patients have impaired immunity and are vulnerable to TB. Hence, we studied the haematological indices of SCA patients with TB in Nigeria. A total of 23 SCA patients with TB were studied in parallel with equal number of age and sex matched SCA patients without TB. SCA patients with TB had significantly lower haematocrit, higher level of circulating sickle cells (CSCs) and similar level of reticulocyte count in comparison to patients without TB. SCA patients with TB had significantly higher mean WBC count associated with higher frequency of neutrophilia in comparison to those without TB. Monocytosis and eosinopenia were exclusively found in SCA patients with TB at frequencies of 52% and 65% respectively. Lymphocyte and basophil counts were normal in all patients with and without TB. Mean platelet counts were high in both patient groups but the frequency of thrombocytosis was significantly higher in patients with TB. SCA patients with TB had significantly higher mean ESR than their counterparts without the infection. The findings of this study revealed that TB in SCA patients was associated with rising level of CSCs, falling level of haematocrit, sub-optimal reticulocytosis, neutrophilia, monocytosis, thrombocytosis, eosinopenia and rising level of ESR. Hence, SCA patients presenting with these haematological indices should be investigated for TB.