Cytokine Changes and Tryptophan Metabolites in Medication-Naive and Medication-Free Schizophrenic Patients
Cytokine Changes and Tryptophan Metabolites in Medication-Naive and Medication-Free Schizophrenic Patients
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DOI：
10.1159/000213565
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发表时间：
2009-01-01
影响因子：
3.2
通讯作者：
Leonard, Brian
中科院分区：
文献类型：
--
作者：
Kim, Yong-Ku;Myint, Aye-Mu;Leonard, Brian
据报道，细胞因子失衡，特别是辅助性T细胞（Th）1和Th 2之间的失衡以及色氨酸分解与精神分裂症的病理生理学有关。过度活跃的炎症反应系统可诱导增强的色氨酸分解。本研究旨在探讨精神分裂症患者与正常对照组细胞因子变化、色氨酸分解参数变化与临床指标的关系。在精神分裂症患者的血浆中，Th 1特异性干扰素-γ显著升高（F = 7.485，p = 0.007），而Th 2特异性白细胞介素（IL）-4显著降低（F = 126.327，p < 0.0001）。精神分裂症患者血浆中Th 1相关细胞因子IL-2较低（F = 5.409，p = 0.021），但肿瘤坏死因子-α（TNF-α）和Th 2相关细胞因子IL-6较高（分别为F = 95.004，p < 0.0001和F = 408.176，p < 0.0001）。治疗6周后，IL-6和TNF-α显著降低（t =-3.762，p < 0.0001和z =-2.668，p = 0.008）。入院时，精神分裂症患者血浆色氨酸浓度较低（F = 6.339，p = 0.012），与阳性症状总评分呈负相关（r（2）=-0.343，p = 0.004）。用药6周后，血浆色氨酸和犬尿氨酸浓度均升高（分别为t =-2.937，p = 0.005和t =-3.214，p = 0.002）。这项研究的结果表明，过度活跃的促炎反应诱导色氨酸代谢的变化，这可能与精神分裂症阳性症状的发展有关。版权所有（C）2009 S. Karger AG，巴塞尔
Cytokine imbalances especially between T helper type (Th) 1 and Th2 and tryptophan breakdown were reported to be involved in the pathophysiology of schizophrenia. The hyperactive inflammatory response system could induce enhanced tryptophan breakdown. This study aimed to investigate the relationship between cytokine changes, tryptophan breakdown parameter changes and clinical parameters in patients with schizophrenia in comparison with normal controls. In the plasma of schizophrenic patients, Th1-specific interferon-gamma was significantly higher (F = 7.485, p = 0.007) and Th2-specific interleukin (IL)-4 was significantly lower (F = 126.327, p < 0.0001). The Th1-related cytokine IL-2 was lower (F = 5.409, p = 0.021) but tumor necrosis factor-alpha (TNF-alpha) and Th2-related IL-6 were higher (F = 95.004, p < 0.0001 and F = 408.176, p < 0.0001, respectively) in the plasma of schizophrenic patients. After 6 weeks of treatment, IL-6 and TNF-alpha were significantly reduced (t = -3.762, p < 0.0001 and z = -2.668, p = 0.008). At the time of admission, plasma tryptophan concentrations were lower (F = 6.339, p = 0.012) in schizophrenic patients and were negatively correlated with the total positive symptoms score (r(2) = -0.343, p = 0.004). After 6 weeks of medication, both plasma tryptophan and kynurenine concentrations were increased (t = -2.937, p = 0.005 and t = -3.214, p = 0.002, respectively). The findings of this study indicate a hyperactive pro-inflammatory response inducing a change in tryptophan metabolism that might be related to the development of positive symptoms in schizophrenia. Copyright (C) 2009 S. Karger AG, Basel