The safety and effects of the beta-blocker, nadolol, in mild asthma: An open-label pilot study
The safety and effects of the beta-blocker, nadolol, in mild asthma: An open-label pilot study
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DOI：
10.1016/j.pupt.2007.07.002
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发表时间：
2008-01-01
影响因子：
3.2
通讯作者：
Bond, Richard A.
中科院分区：
文献类型：
--
作者：
Hanania, Nicola A.;Singh, Supria;Bond, Richard A.
β受体阻滞剂目前在哮喘中禁用，因为其急性给药可能与支气管痉挛恶化相关。然而.它们长期给药的效果和安全性还没有得到很好的评价。这项初步研究的基本原理是基于在充血性心力衰竭中使用β受体阻滞剂时观察到的范式转变，β受体阻滞剂曾因其急性有害作用而被禁用，现在已显示其长期使用可降低死亡率。我们假设某些β受体阻滞剂在慢性哮喘治疗中也是安全有效的。在这项前瞻性、开放标签、先导性研究中，我们评估了10名轻度哮喘受试者接受递增剂量β受体阻滞剂纳多洛尔给药9周的安全性和效果。基于预先确定的安全性、肺功能，每周进行一次剂量递增。哮喘控制和血流动力学参数。主要目的是评价安全性，次要目的是评价气道高反应性和呼吸功能指数的影响。纳多洛尔剂量递增的耐受性良好。在10名受试者中，有8名接受了9周的纳多洛尔治疗，PC（20）呈剂量依赖性显著增加，在40 mg剂量时达到2.1倍剂量（P
Beta-blockers are currently contraindicated in asthma because their acute administration may be associated with worsening bronchospasm. However. their effects and safety with their chronic administration are not well evaluated. The rationale for this pilot study was based on the paradigm shift that was observed with the use of beta-blockers in congestive heart failure, which once contraindicated because of their acute detrimental effects, have now been shown to reduce mortality with their chronic use. We hypothesized that certain beta-blockers may also be safe and useful in chronic asthma therapy. In this prospective, open-label, pilot study, we evaluated the safety and effects of escalating doses of the beta-blocker, nadolol, administered over 9 weeks to 10 Subjects with mild asthma. Dose escalation was performed on a weekly basis based on pre-determined safety, lung function.. asthma control and hemodynamic parameters. The primary objective was to evaluate safety and secondary objectives were to evaluate effects oil airway hyperresponsiveness, and indices of respiratory function. The escalating administration of nadolol was well tolerated. In 8 Out of the 10 subjects, 9 weeks of nadolol treatment produced a significant, dose-dependent increase in PC(20) that reached 2.1 doubling doses at 40 mg (P