Cirrhosis due to Chronic Hepatitis E Infection in a Child Post-Bone Marrow Transplant
Cirrhosis due to Chronic Hepatitis E Infection in a Child Post-Bone Marrow Transplant
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DOI：
10.1016/j.jpeds.2012.01.028
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发表时间：
2012-05-01
影响因子：
5.1
通讯作者：
Alvarez, Fernando
中科院分区：
文献类型：
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作者：
Halac, Ugur;Beland, Kathie;Alvarez, Fernando
慢性戊型肝炎病毒(HEV)感染发生在免疫抑制的成年人中。我们检测了一名青少年患者的血清中HEV核糖核酸，患者接受了骨髓移植，随后出现持续升高的转氨酶和组织学上的慢性肝炎，最终发展为肝硬变。系统进化分析表明，这些HEV毒株与猪3a基因型相似，提示可能是人畜共患病。(《儿科杂志》2012；160：871-4)
Chronic hepatitis E virus (HEV) infection occurs in immunosuppressed adults. We detected HEV ribonucleic acid in serum of an adolescent patient who had undergone bone marrow transplantation and subsequently presented with persistently increased aminotransferases and histologic chronic hepatitis, and eventually developed cirrhosis. Phylogenetic analysis revealed these HEV strains were similar to swine genotype 3a, suggesting a possible zoonosis. (J Pediatr 2012; 160: 871-4)