The effects of brewers' spent grain on high-fat diet-induced fatty liver.
The effects of brewers' spent grain on high-fat diet-induced fatty liver.
复制标题
啤酒糟对高脂饮食诱发的脂肪肝的影响。
DOI：
10.1016/j.bbrc.2022.05.056
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发表时间：
2022
影响因子：
3.1
通讯作者：
Kang,HyeWon
中科院分区：
文献类型：
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作者：
Pei,Ya;Balogun,Olugbenga;Otieno,Dammah;Parks,JohnS;Kang,HyeWon
肥胖会导致非酒精性脂肪肝（NAFLD）。本研究探讨了饮食中添加啤酒糟（BSG）对肥胖诱导的NAFLD的影响。与喂食HFD的小鼠相比，喂食补充有30% BSG的高脂肪饮食（HFD 30）的小鼠体重减轻，血浆总胆固醇（TC）浓度降低。腹膜后白色脂肪组织（RWAT）和肝脏重量降低。与肝脏三酰甘油、TC和非酯化脂肪酸浓度降低一致，饲喂HFD 30的小鼠显示肝脏脂肪变性减少。3-羟基-3-甲基戊二酰辅酶A还原酶和低密度脂蛋白受体基因增加，而肉毒碱棕榈酰转移酶1 α，ATP结合盒亚家族A成员1（ABCA 1），和胆固醇7 α-羟化酶基因上调HFD 30喂养小鼠的肝脏。ABCA 1基因表达在HFD 30喂养小鼠的附睾WAT和RWAT中也增加。BSG补充分别增加和降低粪便脂肪和胆汁酸浓度。总之，BSG补充通过增加肝脏中的脂肪酸氧化和胆汁酸合成以及减少肠道中的脂质吸收来减少HFD诱导的肝脏脂质蓄积。
Obesity develops nonalcoholic fatty liver disease (NAFLD). This study investigated the effects of dietary brewers’ spent grain (BSG) supplementation on obesity-induced NAFLD. Mice fed a high-fat diet supplemented with 30% BSG (HFD30) had reduced body weight and decreased plasma total cholesterol (TC) concentrations compared with HFD-fed mice. Retroperitoneal white adipose tissue (RWAT) and liver weights were reduced. Consistent with reduced hepatic triacylglycerol, TC, and non-esterified fatty acid concentrations, HFD30-fed mice showed reduced hepatic steatosis. 3-hydroxy-3-methylglutaryl-CoA reductase and low-density lipoprotein receptor genes were increased, whereas carnitine palmitoyltransferase 1 alpha, ATP-binding cassette subfamily A member 1 (ABCA1), and cholesterol 7 alpha-hydroxylase genes were upregulated in the liver of HFD30-fed mice. ABCA1 gene expression was also increased in epididymal WAT and RWAT of HFD30-fed mice. BSG supplementation increased and decreased fecal fat and bile acid concentrations, respectively. Taken together, BSG supplementation reduced HFD-induced hepatic lipid accumulation by increasing fatty acid oxidation and bile acid synthesis in the liver as well as decreasing lipid absorption in the intestine.