Three-year antipsychotic effectiveness in the outpatient care of schizophrenia: Observational versus randomized studies results
Three-year antipsychotic effectiveness in the outpatient care of schizophrenia: Observational versus randomized studies results
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DOI：
10.1016/j.euroneuro.2006.09.005
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发表时间：
2007-03-01
影响因子：
5.6
通讯作者：
Naber, Dieter
中科院分区：
文献类型：
--
作者：
Haro, Josep Maria;Suarez, David;Naber, Dieter
抗精神病药物的停用率是精神分裂症药物疗效的一个强有力的指标。我们在精神分裂症门诊健康结局(SOHO)研究中检查了抗精神病药物的停用情况，这是一项对10个欧洲国家的门诊精神分裂症患者进行的为期3年的前瞻性观察性研究。对7728例开始单一抗精神病药物治疗的患者进行分析。因任何原因停药，氯氮平和奥氮平分别为34%和36%，奎硫平为66%。与奥氮平相比，奎硫平、利培酮、阿米舒普利和典型抗精神病药物(口服和仓库)在36个月前停止治疗的风险显著高于奥氮平，但氯氮平的风险相似。药物维持时间较长与积极参加社交活动以及自首次接触精神分裂症治疗以来的时间较长有关，而症状严重程度较高、使用情绪稳定剂治疗、药物滥用、有敌对行为与较低的药物维持时间有关。SOHO患者的抗精神病药物维持率高于之前的随机研究结果。(C)2006年爱思唯尔和ECNP。版权所有。
Antipsychotic discontinuation rates are a powerful indicator of medication effectiveness in schizophrenia. We examined antipsychotic discontinuation in the Schizophrenia Outpatient Health Outcomes (SOHO) study, a 3-year prospective, observational study in outpatients with schizophrenia in 10 European countries. Patients (n=7728) who started antipsychotic monotherapy were analyzed. Medication discontinuation for any cause ranged from 34% and 36% for clozapine and olanzapine, respectively, to 66% for quetiapine. Compared to olanzapine, the risk of treatment discontinuation before 36 months was significantly higher for quetiapine, risperidone, amisulpride, and typical antipsychotics (oral and depot), but similar for clozapine. Longer medication maintenance was associated with being socially active and having a longer time since first treatment contact for schizophrenia, whereas higher symptom severity, treatment with mood stabilizers, substance abuse, having hostile behaviour were associated with lower medication maintenance. Antipsychotic maintenance in SOHO was higher than the results of previous randomized studies. (c) 2006 Elsevier B.V. and ECNP. All rights reserved.