Association of Epicardial Adipose Tissue With Progression of Coronary Artery Calcification Is More Pronounced in the Early Phase of Atherosclerosis Results From the Heinz Nixdorf Recall Study
Association of Epicardial Adipose Tissue With Progression of Coronary Artery Calcification Is More Pronounced in the Early Phase of Atherosclerosis Results From the Heinz Nixdorf Recall Study
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DOI：
10.1016/j.jcmg.2014.07.002
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发表时间：
2014-09-01
影响因子：
14
通讯作者：
Moehlenkamp, Stefan
中科院分区：
文献类型：
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作者：
Mahabadi, Amir A.;Lehmann, Nils;Moehlenkamp, Stefan
目的 本研究旨在确定心外膜脂肪组织 (EAT) 体积是否可以预测一般人群中冠状动脉钙化 (CAC) 评分的进展。背景 EAT 可预测冠状动脉事件，并被认为会影响动脉粥样硬化的发展。方法 我们纳入了基于人群的 Heinz Nixdorf Recall 研究中的 3,367 名受试者（平均年龄 59 +/- 8 岁；47% 为男性），这些受试者均未了解冠状动脉情况基线时有动脉疾病。 CAC 通过基线和 5 年后的非对比心脏电子束计算机断层扫描进行量化。 EAT 被定义为心包囊内的脂肪体积，并通过轴向计算机断层扫描图像进行量化。 EAT 体积与 CAC 进展的关联 (log[CAC(后续) + 1] - log[CAC(基线) + 1]）被描述为每 EAT SD 的 CAC + 1 进展百分比。 结果 CAC 进展高于中位数的受试者比 CAC 变化较小的受试者具有更高的 EAT 体积（101.1 +/- 47.1 ml 与 84.4 +/- 43.4 ml；p < 0.0001）。在回归分析中，CAC + 1 进展的 6.3%（95% 置信区间 [CI]：2.3% 至 10.4%；p = 0.0019）归因于 EAT 的 1 SD，在调整危险因素后，这种情况持续存在（6.1% [95% CI：1.2% 至 11.2%]；p = 0.014）。对于 CAC 评分 >0 至 = 400 的受试者（0.2% [95% CI：-3.5% 至 4.2%]；p = 0.9）。同样，受试者年龄
OBJECTIVES This study sought to determine whether epicardial adipose tissue (EAT) volume predicts the progression of coronary artery calcification (CAC) score in the general population.BACKGROUND EAT predicts coronary events and is suggested to influence the development of atherosclerosis.METHODS We included 3,367 subjects (mean age 59 +/- 8 years; 47% mate) from the population-based Heinz Nixdorf Recall study without known coronary artery disease at baseline. CAC was quantified from noncontrast cardiac electron beam computed tomography at baseline and after 5 years. EAT was defined as fat volume inside the pericardial sac and was quantified from axial computed tomography images. Association of EAT volume with CAC progression (log[CAC(follow-up) + 1] - log[CAC(baseline) + 1]) was depicted as percent progression of CAC + 1 per SD of EAT.RESULTS Subjects with progression of CAC above the median had higher EAT volume than subjects with less CAC change (101.1 +/- 47.1 ml vs. 84.4 +/- 43.4 ml; p < 0.0001). In regression analysis, 6.3% (95% confidence interval [CI]: 2.3% to 10.4%; p = 0.0019) of progression of CAC + 1 was attributable to 1 SD of EAT, which persisted after adjustment for risk factors (6.1% [95% CI: 1.2% to 11.2%]; p = 0.014). For subjects with a CAC score of >0 to = 400 (0.2% [95% CI: -3.5% to 4.2%]; p = 0.9). Likewise, subjects age