ASYMMETRIC COPPER-CATALYZED CYCLOPROPANATION OF TRISUBSTITUTED AND UNSYMMETRICAL CIS-1,2-DISUBSTITUTED OLEFINS - MODIFIED BIS-OXAZOLINE LIGANDS
ASYMMETRIC COPPER-CATALYZED CYCLOPROPANATION OF TRISUBSTITUTED AND UNSYMMETRICAL CIS-1,2-DISUBSTITUTED OLEFINS - MODIFIED BIS-OXAZOLINE LIGANDS
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DOI：
10.1016/0040-4039(91)80110-r
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发表时间：
1991-12-09
影响因子：
1.8
通讯作者：
MASAMUNE, S
中科院分区：
文献类型：
--
作者：
LOWENTHAL, RE;MASAMUNE, S
由相应的氨基醇和丙二酸双亚胺酯合成的新的双恶唑啉（3-7）的Cu（I）配合物在催化三取代和不对称顺式-1，2-二取代烯烃的环丙烷化反应中表现出高达94%ee的高对映选择性。 新的重氮基乙酸酯试剂也已开发，得到高达99：1的反式/顺式比率。
The Cu(I) complexes of new bis-oxazolines (3-7) prepared from the corresponding amino alcohols and malono-bis-imidate exhibit high enantioselectivity of up to 94 %ee in the catalytic cyclopropanation of trisubstituted and unsymmetrical cis-1,2-disubstituted olefins. New diazoacetate reagents have also been developed giving high trans/cis ratios of up to 99:1 trans.