Five New CRF07_BC Near Full-Length Sequences Isolated from Sichuan, China
Five New CRF07_BC Near Full-Length Sequences Isolated from Sichuan, China
复制标题
DOI：
10.1089/aid.2012.0124
复制
发表时间：
2013-01-01
影响因子：
1.5
通讯作者：
Xu, Jianqing
中科院分区：
文献类型：
--
作者：
Meng, Zhefeng;Xin, Ruolei;Xu, Jianqing
从云南省到新疆自治区的主要海洛因贩运被认为启动了CRF07_BC的传播，CRF07_BC是中国静脉吸毒者（IDUs）中的主要菌株。然而，由于云南和新疆之间的距离很远，导致CRF07_BC的扩散过程不清楚，难以预测，因为没有一个重要的中间站点，如四川省。此外，近年来四川凉山地区静脉吸毒人群感染率的迅速上升，使得有必要对四川省静脉吸毒流行株的遗传特征进行研究。本研究对7株新分离的CRF07_BC（5株来自四川，2株来自新疆）的基因组特征进行了分析，并对不同地区静脉吸毒者分离株之间的传播连锁进行了研究。通过马尔可夫链蒙特卡罗（MCMC）分析和相邻连接树和最大似然树的重建，揭示了CRF07_BC四川株的遗传变异及其在CRF07_BC传播中的重要作用。
The main heroine traffic from Yunnan province to the Xinjiang Autonomous Region is believed to initiate the transmission of CRF07_BC which is the predominant strain in intravenous drug users (IDUs) in China. However, the great distances between Yunnan and Xinjiang lead to an unclear and elusive diffusion process of CRF07_BC due to the absence of an important middle site such as Sichuan province. Moreover, in recent years the rapidly increasing infection rate among IDUs in the Liangshan region of Sichuan made it necessary to characterize the genetic character of the circulating strain of Sichuan IDUs. In this study, we characterized the genetic character of seven newly isolated CRF07_BC genomes (five from Sichuan and two from Xinjiang) and analyzed the transmission linkage among strains from IDUs in different regions. By conducting Markov chain Monte Carlo (MCMC) analysis and reconstruction of neighbor-joining trees and maximum-likelihood trees, our results revealed the genetic variation and important role of Sichuan-derived CRF07_BC strains during the transmission of CRF07_BC.